Layer 5 Burst Non-accommodating Neurogliaform Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: burst non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000369
bNAC219_L5_NGC_6186b7e85e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000369
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.64 mV
Rheobase Current Interval (0.02289, 0.02380] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0123 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.1371 mV
AP 1 Steady State Amplitude Change 3.1842 mV
AP 1 Amplitude 53.1196 mV
AP 1 Width at Half Height 0.9800 ms
AP 1 Width (Peak To Trough) 5.6500 ms
AP 1 Rate of Change Peak to Trough -11.9864 mV/ms
AP 1 AHP Depth 14.6037 mV
AP2 Amplitude 51.9824 mV
AP2 Width at Half Height 1.0100 ms
AP 2 Width (Peak to Trough) 5.8100 ms
AP 2 Rate of Change Peak to Trough -11.4992 mV/ms
AP 2 AHP Depth 14.8280 mV
AP 1-2 Amplitude Change Percent -2.1407 %
AP 1-2 Half Width Change Percent 3.0612 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.0647 %
AP 1-2 AHP Depth Percent Change 1.5356 %
Input Resistance 765.5228 MΩ
AP 1 Delay Mean 31.2600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.8300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 41.3700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0743 %/ms
Accommodation at Steady State Mean -68.5665 %
Accommodation Rate Mean at Steady State 166.2041 ms
ISI CV 4.4734
ISI Median 98.9000 ms
ISI Burst Mean Change 9.0978 %
Spike Rate (Strong Stimulation) 32.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.4000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.2400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.4950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2046.1900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.43 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 191.304 µm
Overall Height 119.549 µm
Overall Depth 91.07 µm
Average Diameter 0.716854 µm
Total Length 2413.95 µm
Total Surface 5180.69 µm2
Total Volume 1722.18 µm3
Max Euclidean Distance 128.501 µm
Max Path Distance 161.804 µm
Max Branch Order 8.0
Average Contraction 0.962137
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 29.7495 °
Average Bifurcation Angle Remote 45.3314 °
Fractal Dimension 1.00961
Complexity Summary
State Equations 1531
Optimal Time-Step 0.00535 ms
Relative Complexity 545.92 HH
Model Size
Sections 121
Compartments 151
State Equations 1531
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00535 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 545.92 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.80 %
Max. Stable Time-Step Benchmark Run Time 1458.56 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16526 Hz
CVODE Steps Per AP 262
CVODE Benchmark Run Time 367.41 HH
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