Layer 5 Burst Non-accommodating Neurogliaform Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: burst non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000367
bNAC219_L5_NGC_0a55b16adf_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000367
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.63 mV
Rheobase Current Interval (0.02289, 0.02380] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0123 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.6920 mV
AP 1 Steady State Amplitude Change 2.2893 mV
AP 1 Amplitude 52.1263 mV
AP 1 Width at Half Height 1.0100 ms
AP 1 Width (Peak To Trough) 5.8600 ms
AP 1 Rate of Change Peak to Trough -11.3699 mV/ms
AP 1 AHP Depth 14.5010 mV
AP2 Amplitude 51.4343 mV
AP2 Width at Half Height 1.0400 ms
AP 2 Width (Peak to Trough) 6.0100 ms
AP 2 Rate of Change Peak to Trough -10.9296 mV/ms
AP 2 AHP Depth 14.2527 mV
AP 1-2 Amplitude Change Percent -1.3276 %
AP 1-2 Half Width Change Percent 2.9703 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.8720 %
AP 1-2 AHP Depth Percent Change -1.7125 %
Input Resistance 767.4131 MΩ
AP 1 Delay Mean 31.2400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.4000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 41.0150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0954 %/ms
Accommodation at Steady State Mean -68.9345 %
Accommodation Rate Mean at Steady State 158.9122 ms
ISI CV 4.5281
ISI Median 99.4700 ms
ISI Burst Mean Change 9.4740 %
Spike Rate (Strong Stimulation) 32.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.3000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.0400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.4450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2078.4800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 182.27 µm
Overall Height 123.55 µm
Overall Depth 95.19 µm
Average Diameter 0.716829 µm
Total Length 2395.17 µm
Total Surface 5171.72 µm2
Total Volume 1725.54 µm3
Max Euclidean Distance 117.922 µm
Max Path Distance 150.186 µm
Max Branch Order 8.0
Average Contraction 0.961945
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 27.5204 °
Average Bifurcation Angle Remote 45.5629 °
Fractal Dimension 1.0099
Complexity Summary
State Equations 1551
Optimal Time-Step 0.00524 ms
Relative Complexity 556.99 HH
Model Size
Sections 121
Compartments 153
State Equations 1551
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00524 ms
Optimal Time-Step Error 1.96 %
Optimal Time-Step Benchmark Run Time 556.99 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 2.70 %
Max. Stable Time-Step Benchmark Run Time 1458.83 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16638 Hz
CVODE Steps Per AP 243
CVODE Benchmark Run Time 365.99 HH
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