Layer 5 Burst Non-accommodating Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: burst non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000366
bNAC219_L5_DBC_ec8ca02d79_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000366
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.48 mV
Rheobase Current Interval (0.04005, 0.04166] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0267 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 0.2852 mV
AP 1 Steady State Amplitude Change 2.7566 mV
AP 1 Amplitude 56.8943 mV
AP 1 Width at Half Height 0.8700 ms
AP 1 Width (Peak To Trough) 5.3500 ms
AP 1 Rate of Change Peak to Trough -13.2278 mV/ms
AP 1 AHP Depth 13.8743 mV
AP2 Amplitude 56.6090 mV
AP2 Width at Half Height 0.8700 ms
AP 2 Width (Peak to Trough) 5.5000 ms
AP 2 Rate of Change Peak to Trough -12.8562 mV/ms
AP 2 AHP Depth 14.1002 mV
AP 1-2 Amplitude Change Percent -0.5013 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.8088 %
AP 1-2 AHP Depth Percent Change 1.6283 %
Input Resistance 364.3534 MΩ
AP 1 Delay Mean 35.3900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 78.5500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 45.3550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0710 %/ms
Accommodation at Steady State Mean -68.1886 %
Accommodation Rate Mean at Steady State 182.7343 ms
ISI CV 4.4885
ISI Median 107.5150 ms
ISI Burst Mean Change 10.1715 %
Spike Rate (Strong Stimulation) 24.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 31.3200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.4250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2072.0400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10132.8 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 184.446 µm
Overall Height 315.792 µm
Overall Depth 130.36 µm
Average Diameter 1.43869 µm
Total Length 2452.0 µm
Total Surface 10243.2 µm2
Total Volume 6020.79 µm3
Max Euclidean Distance 186.291 µm
Max Path Distance 240.225 µm
Max Branch Order 6.0
Average Contraction 0.977343
Total Fragmentation 903.0
Partition Asymmetry 0.413136
Average Rall's Ratio 1.066
Average Bifurcation Angle Local 21.717 °
Average Bifurcation Angle Remote 42.7333 °
Fractal Dimension 1.00311
Complexity Summary
State Equations 1231
Optimal Time-Step 0.00759 ms
Relative Complexity 301.05 HH
Model Size
Sections 63
Compartments 121
State Equations 1231
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00759 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 301.05 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.26 %
Max. Stable Time-Step Benchmark Run Time 570.87 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14197 Hz
CVODE Steps Per AP 322
CVODE Benchmark Run Time 261.64 HH
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