Layer 5 Burst Non-accommodating Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: burst non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst non-accommodating double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000365
bNAC219_L5_DBC_d56fbcd5cf_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000365
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.51 mV
Rheobase Current Interval (0.04395, 0.04578] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0517 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 0.3167 mV
AP 1 Steady State Amplitude Change 1.7920 mV
AP 1 Amplitude 54.7699 mV
AP 1 Width at Half Height 0.8900 ms
AP 1 Width (Peak To Trough) 4.5900 ms
AP 1 Rate of Change Peak to Trough -14.0718 mV/ms
AP 1 AHP Depth 9.8198 mV
AP2 Amplitude 54.4532 mV
AP2 Width at Half Height 0.8800 ms
AP 2 Width (Peak to Trough) 4.6700 ms
AP 2 Rate of Change Peak to Trough -13.8094 mV/ms
AP 2 AHP Depth 10.0366 mV
AP 1-2 Amplitude Change Percent -0.5782 %
AP 1-2 Half Width Change Percent -1.1236 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.8650 %
AP 1-2 AHP Depth Percent Change 2.2079 %
Input Resistance 242.4305 MΩ
AP 1 Delay Mean 49.7700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 92.8600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 44.8900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0636 %/ms
Accommodation at Steady State Mean -64.3173 %
Accommodation Rate Mean at Steady State 216.4701 ms
ISI CV 4.6487
ISI Median 98.9200 ms
ISI Burst Mean Change 8.3546 %
Spike Rate (Strong Stimulation) 27.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.8900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 33.4000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.0700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2071.0600 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5072 Hz
Frequency Filter Pass Below 79.2337 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9840.66 µm2
Number of Stems 7.0
Number of Bifurcations 36.0
Number of Branches 78.0
Overall Width 288.422 µm
Overall Height 720.82 µm
Overall Depth 136.55 µm
Average Diameter 1.21302 µm
Total Length 4951.52 µm
Total Surface 17584.4 µm2
Total Volume 7673.86 µm3
Max Euclidean Distance 607.18 µm
Max Path Distance 615.926 µm
Max Branch Order 7.0
Average Contraction 0.968659
Total Fragmentation 1862.0
Partition Asymmetry 0.477888
Average Rall's Ratio 1.82983
Average Bifurcation Angle Local 27.6869 °
Average Bifurcation Angle Remote 42.8878 °
Fractal Dimension 1.00514
Complexity Summary
Relative Complexity 460.91 HH
State Equations 2391
Optimal Time-Step 0.00774 ms
Model Size
Sections 81
Compartments 237
State Equations 2391
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13017 Hz
CVODE Steps Per AP 287
CVODE Benchmark Run Time 460.91 HH
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