Layer 5 Burst Non-accommodating Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: burst non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000362
bNAC219_L5_DBC_0024418c1a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000362
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.43 mV
Rheobase Current Interval (0.04005, 0.04166] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0271 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 0.1165 mV
AP 1 Steady State Amplitude Change 2.4087 mV
AP 1 Amplitude 57.1995 mV
AP 1 Width at Half Height 0.8500 ms
AP 1 Width (Peak To Trough) 5.3400 ms
AP 1 Rate of Change Peak to Trough -13.3519 mV/ms
AP 1 AHP Depth 14.0998 mV
AP2 Amplitude 57.0830 mV
AP2 Width at Half Height 0.8500 ms
AP 2 Width (Peak to Trough) 5.4900 ms
AP 2 Rate of Change Peak to Trough -12.9837 mV/ms
AP 2 AHP Depth 14.1977 mV
AP 1-2 Amplitude Change Percent -0.2036 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.7575 %
AP 1-2 AHP Depth Percent Change 0.6944 %
Input Resistance 360.0923 MΩ
AP 1 Delay Mean 35.7400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 79.2000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 45.5600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0721 %/ms
Accommodation at Steady State Mean -67.4557 %
Accommodation Rate Mean at Steady State 187.0632 ms
ISI CV 4.5139
ISI Median 106.4400 ms
ISI Burst Mean Change 9.6641 %
Spike Rate (Strong Stimulation) 24.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.6600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 31.5500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.5100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2068.7500 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10132.8 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 181.629 µm
Overall Height 366.926 µm
Overall Depth 125.57 µm
Average Diameter 1.43876 µm
Total Length 2484.92 µm
Total Surface 10384.1 µm2
Total Volume 6062.81 µm3
Max Euclidean Distance 214.259 µm
Max Path Distance 243.007 µm
Max Branch Order 6.0
Average Contraction 0.976979
Total Fragmentation 903.0
Partition Asymmetry 0.413136
Average Rall's Ratio 1.066
Average Bifurcation Angle Local 23.1296 °
Average Bifurcation Angle Remote 43.3594 °
Fractal Dimension 1.00336
Complexity Summary
State Equations 1251
Optimal Time-Step 0.00775 ms
Relative Complexity 306.66 HH
Model Size
Sections 63
Compartments 123
State Equations 1251
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 306.66 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.28 %
Max. Stable Time-Step Benchmark Run Time 593.70 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14306 Hz
CVODE Steps Per AP 325
CVODE Benchmark Run Time 274.20 HH
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