Layer 4 Burst Non-accommodating Small Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket, biophysical, burst non-accommodating small basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000356
bNAC219_L4_SBC_dbf40425f3_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000356
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.45 mV
Rheobase Current Interval (0.01740, 0.01831] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0138 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.0916 mV
AP 1 Steady State Amplitude Change 1.6675 mV
AP 1 Amplitude 62.2401 mV
AP 1 Width at Half Height 0.7400 ms
AP 1 Width (Peak To Trough) 4.5400 ms
AP 1 Rate of Change Peak to Trough -17.3706 mV/ms
AP 1 AHP Depth 16.6224 mV
AP2 Amplitude 62.1485 mV
AP2 Width at Half Height 0.7500 ms
AP 2 Width (Peak to Trough) 4.5900 ms
AP 2 Rate of Change Peak to Trough -17.1728 mV/ms
AP 2 AHP Depth 16.6746 mV
AP 1-2 Amplitude Change Percent -0.1471 %
AP 1-2 Half Width Change Percent 1.3514 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.1387 %
AP 1-2 AHP Depth Percent Change 0.3142 %
Input Resistance 710.2484 MΩ
AP 1 Delay Mean 39.3700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 89.9500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.2600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.0479 %/ms
Accommodation at Steady State Mean -64.9698 %
Accommodation Rate Mean at Steady State 203.2047 ms
ISI CV 4.6048
ISI Median 119.1850 ms
ISI Burst Mean Change 10.5971 %
Spike Rate (Strong Stimulation) 18.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.0000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 35.4500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.2300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2060.0000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3111.02 µm2
Number of Stems 4.0
Number of Bifurcations 24.0
Number of Branches 51.0
Overall Width 226.717 µm
Overall Height 344.603 µm
Overall Depth 104.17 µm
Average Diameter 0.947101 µm
Total Length 1886.16 µm
Total Surface 5145.07 µm2
Total Volume 2100.21 µm3
Max Euclidean Distance 300.502 µm
Max Path Distance 333.823 µm
Max Branch Order 6.0
Average Contraction 0.971146
Total Fragmentation 581.0
Partition Asymmetry 0.455556
Average Rall's Ratio 1.34038
Average Bifurcation Angle Local 25.2529 °
Average Bifurcation Angle Remote 51.7332 °
Fractal Dimension 1.00339
Complexity Summary
Relative Complexity 201.36 HH
State Equations 921
Optimal Time-Step 0.00775 ms
Model Size
Sections 52
Compartments 90
State Equations 921
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14713 Hz
CVODE Steps Per AP 359
CVODE Benchmark Run Time 201.36 HH
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