Layer 4 Burst Non-accommodating Small Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket, biophysical, burst non-accommodating small basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000353
bNAC219_L4_SBC_20e5caa0d2_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000353
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.08 mV
Rheobase Current Interval (0.02472, 0.02609] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0204 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 0.0799 mV
AP 1 Steady State Amplitude Change 1.8179 mV
AP 1 Amplitude 54.4689 mV
AP 1 Width at Half Height 0.9800 ms
AP 1 Width (Peak To Trough) 6.8800 ms
AP 1 Rate of Change Peak to Trough -9.4651 mV/ms
AP 1 AHP Depth 10.6512 mV
AP2 Amplitude 54.3889 mV
AP2 Width at Half Height 0.9800 ms
AP 2 Width (Peak to Trough) 7.1600 ms
AP 2 Rate of Change Peak to Trough -9.0950 mV/ms
AP 2 AHP Depth 10.7313 mV
AP 1-2 Amplitude Change Percent -0.1467 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.9103 %
AP 1-2 AHP Depth Percent Change 0.7523 %
Input Resistance 500.6372 MΩ
AP 1 Delay Mean 46.8300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 96.6400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 52.5350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0753 %/ms
Accommodation at Steady State Mean -64.6818 %
Accommodation Rate Mean at Steady State 205.9512 ms
ISI CV 4.5942
ISI Median 116.6700 ms
ISI Burst Mean Change 10.9416 %
Spike Rate (Strong Stimulation) 19.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.4500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 21.3950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2061.6600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5445.33 µm2
Number of Stems 10.0
Number of Bifurcations 23.0
Number of Branches 55.0
Overall Width 234.821 µm
Overall Height 276.256 µm
Overall Depth 178.9 µm
Average Diameter 0.895907 µm
Total Length 3595.89 µm
Total Surface 8666.0 µm2
Total Volume 2963.1 µm3
Max Euclidean Distance 197.794 µm
Max Path Distance 231.41 µm
Max Branch Order 4.0
Average Contraction 0.950083
Total Fragmentation 1214.0
Partition Asymmetry 0.35942
Average Rall's Ratio 2.31143
Average Bifurcation Angle Local 60.0802 °
Average Bifurcation Angle Remote 74.3013 °
Fractal Dimension 1.00629
Complexity Summary
Relative Complexity 375.80 HH
State Equations 1791
Optimal Time-Step 0.00764 ms
Model Size
Sections 55
Compartments 177
State Equations 1791
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14434 Hz
CVODE Steps Per AP 293
CVODE Benchmark Run Time 375.80 HH
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