Layer 4 Burst Non-accommodating Neurogliaform Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000351
bNAC219_L4_NGC_f7ede76c77_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000351
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.35 mV
Rheobase Current Interval (0.06088, 0.06248] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0256 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 1.1017 mV
AP 1 Steady State Amplitude Change 5.8201 mV
AP 1 Amplitude 51.5408 mV
AP 1 Width at Half Height 0.8900 ms
AP 1 Width (Peak To Trough) 4.4300 ms
AP 1 Rate of Change Peak to Trough -14.2419 mV/ms
AP 1 AHP Depth 11.5510 mV
AP2 Amplitude 50.4391 mV
AP2 Width at Half Height 0.9100 ms
AP 2 Width (Peak to Trough) 4.5900 ms
AP 2 Rate of Change Peak to Trough -13.5294 mV/ms
AP 2 AHP Depth 11.6607 mV
AP 1-2 Amplitude Change Percent -2.1375 %
AP 1-2 Half Width Change Percent 2.2472 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.0033 %
AP 1-2 AHP Depth Percent Change 0.9497 %
Input Resistance 367.9357 MΩ
AP 1 Delay Mean 23.2900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 48.1900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 27.8400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.0638 %/ms
Accommodation at Steady State Mean -65.6805 %
Accommodation Rate Mean at Steady State 150.3647 ms
ISI CV 5.3189
ISI Median 59.3600 ms
ISI Burst Mean Change 23.6145 %
Spike Rate (Strong Stimulation) 65.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.9600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.7200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.7550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2026.2800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9850.78 µm2
Number of Stems 9.0
Number of Bifurcations 78.0
Number of Branches 164.0
Overall Width 140.09 µm
Overall Height 198.724 µm
Overall Depth 121.05 µm
Average Diameter 0.864297 µm
Total Length 4272.17 µm
Total Surface 10588.4 µm2
Total Volume 4963.95 µm3
Max Euclidean Distance 156.633 µm
Max Path Distance 253.497 µm
Max Branch Order 9.0
Average Contraction 0.960287
Total Fragmentation 1593.0
Partition Asymmetry 0.456598
Average Rall's Ratio 1.11713
Average Bifurcation Angle Local 33.8535 °
Average Bifurcation Angle Remote 68.5596 °
Fractal Dimension 1.00638
Complexity Summary
State Equations 2291
Optimal Time-Step 0.00535 ms
Relative Complexity 836.60 HH
Model Size
Sections 161
Compartments 227
State Equations 2291
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00535 ms
Optimal Time-Step Error 0.08 %
Optimal Time-Step Benchmark Run Time 836.60 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.52 %
Max. Stable Time-Step Benchmark Run Time 2237.80 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18413 Hz
CVODE Steps Per AP 67
CVODE Benchmark Run Time 561.77 HH
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