Layer 4 Burst Non-accommodating Neurogliaform Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000350
bNAC219_L4_NGC_c0136fa0a8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000350
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.26 mV
Rheobase Current Interval (0.06088, 0.06248] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0258 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 1.1855 mV
AP 1 Steady State Amplitude Change 6.0106 mV
AP 1 Amplitude 51.7776 mV
AP 1 Width at Half Height 0.8800 ms
AP 1 Width (Peak To Trough) 4.3000 ms
AP 1 Rate of Change Peak to Trough -14.6677 mV/ms
AP 1 AHP Depth 11.2936 mV
AP2 Amplitude 50.5921 mV
AP2 Width at Half Height 0.9000 ms
AP 2 Width (Peak to Trough) 4.4500 ms
AP 2 Rate of Change Peak to Trough -13.9391 mV/ms
AP 2 AHP Depth 11.4367 mV
AP 1-2 Amplitude Change Percent -2.2896 %
AP 1-2 Half Width Change Percent 2.2727 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.9677 %
AP 1-2 AHP Depth Percent Change 1.2673 %
Input Resistance 360.9339 MΩ
AP 1 Delay Mean 23.6700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 48.3500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 27.6850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.0638 %/ms
Accommodation at Steady State Mean -65.9652 %
Accommodation Rate Mean at Steady State 150.5441 ms
ISI CV 5.3290
ISI Median 59.3500 ms
ISI Burst Mean Change 24.3517 %
Spike Rate (Strong Stimulation) 65.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.5700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.9000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.4100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2027.2900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 72.7219 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9850.78 µm2
Number of Stems 9.0
Number of Bifurcations 78.0
Number of Branches 164.0
Overall Width 170.68 µm
Overall Height 200.214 µm
Overall Depth 134.54 µm
Average Diameter 0.864296 µm
Total Length 4365.9 µm
Total Surface 10964.5 µm2
Total Volume 5103.07 µm3
Max Euclidean Distance 162.212 µm
Max Path Distance 265.648 µm
Max Branch Order 9.0
Average Contraction 0.960648
Total Fragmentation 1593.0
Partition Asymmetry 0.456598
Average Rall's Ratio 1.11713
Average Bifurcation Angle Local 33.8733 °
Average Bifurcation Angle Remote 67.7988 °
Fractal Dimension 1.00654
Complexity Summary
State Equations 2311
Optimal Time-Step 0.00537 ms
Relative Complexity 825.33 HH
Model Size
Sections 161
Compartments 229
State Equations 2311
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00537 ms
Optimal Time-Step Error 0.08 %
Optimal Time-Step Benchmark Run Time 825.33 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.51 %
Max. Stable Time-Step Benchmark Run Time 2215.05 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17547 Hz
CVODE Steps Per AP 130
CVODE Benchmark Run Time 549.10 HH
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