Layer 4 Burst Non-accommodating Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000346
bNAC219_L4_MC_ba3c5063e4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: Ramp current injection produces subthreshold spikelets only.
Model Id: NMLCL000346
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.58 mV
Rheobase Current Interval (0.17784, 0.17944] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0253 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 7.1845 mV
AP 1 Steady State Amplitude Change N/A mV
AP 1 Amplitude 62.3588 mV
AP 1 Width at Half Height 0.7200 ms
AP 1 Width (Peak To Trough) 3.2400 ms
AP 1 Rate of Change Peak to Trough -21.6757 mV/ms
AP 1 AHP Depth 7.8703 mV
AP2 Amplitude 55.1743 mV
AP2 Width at Half Height 0.8800 ms
AP 2 Width (Peak to Trough) 3.4800 ms
AP 2 Rate of Change Peak to Trough -17.3221 mV/ms
AP 2 AHP Depth 5.1066 mV
AP 1-2 Amplitude Change Percent -11.5213 %
AP 1-2 Half Width Change Percent 22.2222 %
AP 1-2 Rate of Change Peak to Trough Percent Change -20.0850 %
AP 1-2 AHP Depth Percent Change -35.1152 %
Input Resistance 240.4080 MΩ
AP 1 Delay Mean 4.0900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 13.4200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 9.2600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -100.0000 %
Steady State Accommodation Mean -100.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -97.8803 %
Accommodation Rate Mean at Steady State 78396.1292 ms
ISI CV 94.6506
ISI Median 9.3300 ms
ISI Burst Mean Change -1.5005 %
Spike Rate (Strong Stimulation) 3.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.8900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 9.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.1450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 5000.0000 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 87.5614 Hz
Frequency Filter Pass Below 94.4386 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9639.21 µm2
Number of Stems 4.0
Number of Bifurcations 31.0
Number of Branches 65.0
Overall Width 223.566 µm
Overall Height 262.462 µm
Overall Depth 137.48 µm
Average Diameter 0.875992 µm
Total Length 3337.76 µm
Total Surface 8530.21 µm2
Total Volume 4614.24 µm3
Max Euclidean Distance 232.424 µm
Max Path Distance 281.513 µm
Max Branch Order 6.0
Average Contraction 0.958833
Total Fragmentation 1224.0
Partition Asymmetry 0.496621
Average Rall's Ratio 0.897045
Average Bifurcation Angle Local 41.0153 °
Average Bifurcation Angle Remote 63.1653 °
Fractal Dimension 1.00613
Complexity Summary
State Equations 1661
Optimal Time-Step 0.00553 ms
Relative Complexity 534.19 HH
Model Size
Sections 66
Compartments 164
State Equations 1661
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00553 ms
Optimal Time-Step Error 0.48 %
Optimal Time-Step Benchmark Run Time 534.19 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 3.39 %
Max. Stable Time-Step Benchmark Run Time 1476.92 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 42282 Hz
CVODE Steps Per AP 2049
CVODE Benchmark Run Time 1219.22 HH
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