Layer 4 Burst Non-accommodating Martinotti Cell (4)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000345
bNAC219_L4_MC_8a4a02932c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000345
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.89 mV
Rheobase Current Interval (0.03113, 0.03204] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0237 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.3452 mV
AP 1 Steady State Amplitude Change 3.8862 mV
AP 1 Amplitude 63.2277 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.0000 ms
AP 1 Rate of Change Peak to Trough -24.6617 mV/ms
AP 1 AHP Depth 10.7572 mV
AP2 Amplitude 62.8826 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 3.0500 ms
AP 2 Rate of Change Peak to Trough -24.1920 mV/ms
AP 2 AHP Depth 10.9030 mV
AP 1-2 Amplitude Change Percent -0.5459 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.9045 %
AP 1-2 AHP Depth Percent Change 1.3547 %
Input Resistance 442.1231 MΩ
AP 1 Delay Mean 30.7700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 61.8500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.0750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -42.8571 %
Steady State Accommodation Mean -42.8571 %
Accommodation Rate to Steady State -0.1099 %/ms
Accommodation at Steady State Mean -77.0727 %
Accommodation Rate Mean at Steady State 152.6279 ms
ISI CV 4.0003
ISI Median 97.3200 ms
ISI Burst Mean Change 12.8378 %
Spike Rate (Strong Stimulation) 29.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.3500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 23.8300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.1500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2041.0500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 124.7296 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6291.11 µm2
Number of Stems 4.0
Number of Bifurcations 40.0
Number of Branches 83.0
Overall Width 258.858 µm
Overall Height 445.434 µm
Overall Depth 205.14 µm
Average Diameter 0.68263 µm
Total Length 3964.41 µm
Total Surface 8118.13 µm2
Total Volume 3035.29 µm3
Max Euclidean Distance 403.398 µm
Max Path Distance 450.419 µm
Max Branch Order 9.0
Average Contraction 0.969259
Total Fragmentation 1582.0
Partition Asymmetry 0.599232
Average Rall's Ratio 1.11412
Average Bifurcation Angle Local 56.9128 °
Average Bifurcation Angle Remote 71.4764 °
Fractal Dimension 1.00536
Complexity Summary
State Equations 2081
Optimal Time-Step 0.00766 ms
Relative Complexity 516.65 HH
Model Size
Sections 84
Compartments 206
State Equations 2081
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00766 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 516.65 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.10 %
Max. Stable Time-Step Benchmark Run Time 988.60 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13781 Hz
CVODE Steps Per AP 324
CVODE Benchmark Run Time 442.74 HH
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