Layer 4 Burst Non-accommodating Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000339
bNAC219_L4_DBC_519f8feedc_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000339
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.95 mV
Rheobase Current Interval (0.04944, 0.05035] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0300 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.1286 mV
AP 1 Steady State Amplitude Change 3.7604 mV
AP 1 Amplitude 68.9022 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 2.4000 ms
AP 1 Rate of Change Peak to Trough -37.1554 mV/ms
AP 1 AHP Depth 20.2707 mV
AP2 Amplitude 69.0308 mV
AP2 Width at Half Height 0.5500 ms
AP 2 Width (Peak to Trough) 2.3900 ms
AP 2 Rate of Change Peak to Trough -37.3958 mV/ms
AP 2 AHP Depth 20.3451 mV
AP 1-2 Amplitude Change Percent 0.1866 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.6470 %
AP 1-2 AHP Depth Percent Change 0.3673 %
Input Resistance 339.5958 MΩ
AP 1 Delay Mean 25.5600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 52.9800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 28.5750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -37.5000 %
Accommodation Rate to Steady State -0.0991 %/ms
Accommodation at Steady State Mean -75.3396 %
Accommodation Rate Mean at Steady State 153.8971 ms
ISI CV 4.2070
ISI Median 80.9200 ms
ISI Burst Mean Change 8.4245 %
Spike Rate (Strong Stimulation) 51.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.3700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.6800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.4600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.4700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11222.4 µm2
Number of Stems 4.0
Number of Bifurcations 30.0
Number of Branches 63.0
Overall Width 148.547 µm
Overall Height 703.615 µm
Overall Depth 183.97 µm
Average Diameter 0.914316 µm
Total Length 3139.57 µm
Total Surface 9625.75 µm2
Total Volume 6564.38 µm3
Max Euclidean Distance 507.049 µm
Max Path Distance 570.397 µm
Max Branch Order 6.0
Average Contraction 0.912086
Total Fragmentation 3461.0
Partition Asymmetry 0.406111
Average Rall's Ratio 0.4202
Average Bifurcation Angle Local 28.5915 °
Average Bifurcation Angle Remote 66.0873 °
Fractal Dimension 1.01967
Complexity Summary
State Equations 1681
Optimal Time-Step 0.00779 ms
Relative Complexity 415.11 HH
Model Size
Sections 64
Compartments 166
State Equations 1681
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.46 %
Optimal Time-Step Benchmark Run Time 415.11 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 3.01 %
Max. Stable Time-Step Benchmark Run Time 807.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13182 Hz
CVODE Steps Per AP 327
CVODE Benchmark Run Time 349.72 HH
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