Layer 4 Burst Non-accommodating Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000337
bNAC219_L4_DBC_0d7219bf46_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000337
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.39 mV
Rheobase Current Interval (0.04395, 0.04463] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0226 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.1788 mV
AP 1 Steady State Amplitude Change 5.5694 mV
AP 1 Amplitude 75.2837 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 1.7800 ms
AP 1 Rate of Change Peak to Trough -54.6724 mV/ms
AP 1 AHP Depth 22.0332 mV
AP2 Amplitude 75.1049 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 1.7800 ms
AP 2 Rate of Change Peak to Trough -54.6002 mV/ms
AP 2 AHP Depth 22.0834 mV
AP 1-2 Amplitude Change Percent -0.2375 %
AP 1-2 Half Width Change Percent -2.1739 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.1321 %
AP 1-2 AHP Depth Percent Change 0.2281 %
Input Resistance 428.9524 MΩ
AP 1 Delay Mean 19.4300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 41.0200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 23.0550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -37.5000 %
Accommodation Rate to Steady State -0.1254 %/ms
Accommodation at Steady State Mean -82.2501 %
Accommodation Rate Mean at Steady State 118.2841 ms
ISI CV 3.9915
ISI Median 80.4750 ms
ISI Burst Mean Change 13.5711 %
Spike Rate (Strong Stimulation) 64.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.2000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.7400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.6900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2017.2700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.1476 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9401.36 µm2
Number of Stems 6.0
Number of Bifurcations 30.0
Number of Branches 65.0
Overall Width 217.002 µm
Overall Height 380.508 µm
Overall Depth 161.97 µm
Average Diameter 0.702502 µm
Total Length 3444.39 µm
Total Surface 6980.68 µm2
Total Volume 4263.27 µm3
Max Euclidean Distance 345.675 µm
Max Path Distance 375.977 µm
Max Branch Order 6.0
Average Contraction 0.927717
Total Fragmentation 3048.0
Partition Asymmetry 0.358802
Average Rall's Ratio 0.39875
Average Bifurcation Angle Local 63.3079 °
Average Bifurcation Angle Remote 68.6606 °
Fractal Dimension 1.01484
Complexity Summary
State Equations 1761
Optimal Time-Step 0.00749 ms
Relative Complexity 433.43 HH
Model Size
Sections 66
Compartments 174
State Equations 1761
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00749 ms
Optimal Time-Step Error 0.49 %
Optimal Time-Step Benchmark Run Time 433.43 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.97 %
Max. Stable Time-Step Benchmark Run Time 810.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13607 Hz
CVODE Steps Per AP 324
CVODE Benchmark Run Time 359.56 HH
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