Layer 4 Burst Non-accommodating Bipolar Cell (3)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: burst non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000334
bNAC219_L4_BP_b88746aff4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000334
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.54 mV
Rheobase Current Interval (0.01190, 0.01213] nA
Threshold Current Interval (0.00000, 0.05859] nA
Bias Current (to -80.00 mV) -0.0100 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop -0.1307 mV
AP 1 Steady State Amplitude Change 3.2188 mV
AP 1 Amplitude 81.5941 mV
AP 1 Width at Half Height 0.4200 ms
AP 1 Width (Peak To Trough) 1.7100 ms
AP 1 Rate of Change Peak to Trough -61.6681 mV/ms
AP 1 AHP Depth 23.8583 mV
AP2 Amplitude 81.7247 mV
AP2 Width at Half Height 0.4300 ms
AP 2 Width (Peak to Trough) 1.6700 ms
AP 2 Rate of Change Peak to Trough -63.1600 mV/ms
AP 2 AHP Depth 23.7524 mV
AP 1-2 Amplitude Change Percent 0.1601 %
AP 1-2 Half Width Change Percent 2.3810 %
AP 1-2 Rate of Change Peak to Trough Percent Change 2.4193 %
AP 1-2 AHP Depth Percent Change -0.4438 %
Input Resistance 1028.9969 MΩ
AP 1 Delay Mean 12.8900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 31.8000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 28.8600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1203 %/ms
Accommodation at Steady State Mean -91.7028 %
Accommodation Rate Mean at Steady State 90.6814 ms
ISI CV 3.4578
ISI Median 132.3250 ms
ISI Burst Mean Change 105.2353 %
Spike Rate (Strong Stimulation) 16.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.1600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.7100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.9700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2027.3500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 131.3747 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 64.6947 µm
Overall Height 813.723 µm
Overall Depth 39.99 µm
Average Diameter 1.07428 µm
Total Length 1186.19 µm
Total Surface 2421.52 µm2
Total Volume 869.922 µm3
Max Euclidean Distance 844.48 µm
Max Path Distance 861.986 µm
Max Branch Order 6.0
Average Contraction 0.990599
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 51.0201 °
Average Bifurcation Angle Remote 46.9325 °
Fractal Dimension 1.00189
Complexity Summary
State Equations 641
Optimal Time-Step 0.00795 ms
Relative Complexity 145.21 HH
Model Size
Sections 16
Compartments 62
State Equations 641
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00795 ms
Optimal Time-Step Error 0.25 %
Optimal Time-Step Benchmark Run Time 145.21 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.10 %
Max. Stable Time-Step Benchmark Run Time 288.37 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14290 Hz
CVODE Steps Per AP 434
CVODE Benchmark Run Time 141.38 HH
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