Layer 2/3 Burst Non-accommodating Small Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000327
bNAC219_L23_SBC_1361ded4e5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000327
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.12 mV
Rheobase Current Interval (0.02563, 0.02655] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0142 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.4911 mV
AP 1 Steady State Amplitude Change 2.5887 mV
AP 1 Amplitude 63.8286 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 4.3300 ms
AP 1 Rate of Change Peak to Trough -19.2723 mV/ms
AP 1 AHP Depth 19.6206 mV
AP2 Amplitude 63.3376 mV
AP2 Width at Half Height 0.7000 ms
AP 2 Width (Peak to Trough) 4.3600 ms
AP 2 Rate of Change Peak to Trough -19.1281 mV/ms
AP 2 AHP Depth 20.0611 mV
AP 1-2 Amplitude Change Percent -0.7694 %
AP 1-2 Half Width Change Percent -1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.7482 %
AP 1-2 AHP Depth Percent Change 2.2454 %
Input Resistance 605.8381 MΩ
AP 1 Delay Mean 28.2300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 68.7100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 43.2850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0987 %/ms
Accommodation at Steady State Mean -74.0694 %
Accommodation Rate Mean at Steady State 153.1281 ms
ISI CV 4.0988
ISI Median 118.1150 ms
ISI Burst Mean Change 13.8587 %
Spike Rate (Strong Stimulation) 19.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.2000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.6900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.2150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2045.8500 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5333.94 µm2
Number of Stems 8.0
Number of Bifurcations 16.0
Number of Branches 39.0
Overall Width 172.462 µm
Overall Height 370.88 µm
Overall Depth 193.71 µm
Average Diameter 0.929717 µm
Total Length 2259.16 µm
Total Surface 5369.38 µm2
Total Volume 2409.29 µm3
Max Euclidean Distance 302.502 µm
Max Path Distance 309.291 µm
Max Branch Order 4.0
Average Contraction 0.975225
Total Fragmentation 568.0
Partition Asymmetry 0.45
Average Rall's Ratio 1.35125
Average Bifurcation Angle Local 31.1172 °
Average Bifurcation Angle Remote 50.8955 °
Fractal Dimension 1.00377
Complexity Summary
State Equations 1121
Optimal Time-Step 0.00774 ms
Relative Complexity 256.62 HH
Model Size
Sections 40
Compartments 110
State Equations 1121
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.32 %
Optimal Time-Step Benchmark Run Time 256.62 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.95 %
Max. Stable Time-Step Benchmark Run Time 496.19 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14868 Hz
CVODE Steps Per AP 343
CVODE Benchmark Run Time 238.91 HH
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