Layer 2/3 Burst Non-accommodating Neurogliaform Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000326
bNAC219_L23_NGC_d600988347_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000326
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.35 mV
Rheobase Current Interval (0.06088, 0.06248] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0255 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 1.1130 mV
AP 1 Steady State Amplitude Change 6.1959 mV
AP 1 Amplitude 52.0834 mV
AP 1 Width at Half Height 0.8700 ms
AP 1 Width (Peak To Trough) 4.3800 ms
AP 1 Rate of Change Peak to Trough -14.5039 mV/ms
AP 1 AHP Depth 11.4437 mV
AP2 Amplitude 50.9704 mV
AP2 Width at Half Height 0.8900 ms
AP 2 Width (Peak to Trough) 4.5400 ms
AP 2 Rate of Change Peak to Trough -13.7678 mV/ms
AP 2 AHP Depth 11.5353 mV
AP 1-2 Amplitude Change Percent -2.1369 %
AP 1-2 Half Width Change Percent 2.2989 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.0753 %
AP 1-2 AHP Depth Percent Change 0.8005 %
Input Resistance 368.5359 MΩ
AP 1 Delay Mean 23.2400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 48.2500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 27.9000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.0644 %/ms
Accommodation at Steady State Mean -65.2561 %
Accommodation Rate Mean at Steady State 151.5509 ms
ISI CV 5.3892
ISI Median 58.9000 ms
ISI Burst Mean Change 23.1108 %
Spike Rate (Strong Stimulation) 65.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.8000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.6700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.8050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2025.8600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9850.78 µm2
Number of Stems 9.0
Number of Bifurcations 78.0
Number of Branches 164.0
Overall Width 145.008 µm
Overall Height 190.452 µm
Overall Depth 136.05 µm
Average Diameter 0.864296 µm
Total Length 4264.75 µm
Total Surface 10569.3 µm2
Total Volume 4968.86 µm3
Max Euclidean Distance 146.44 µm
Max Path Distance 223.139 µm
Max Branch Order 9.0
Average Contraction 0.960158
Total Fragmentation 1593.0
Partition Asymmetry 0.456598
Average Rall's Ratio 1.11713
Average Bifurcation Angle Local 30.7014 °
Average Bifurcation Angle Remote 68.6999 °
Fractal Dimension 1.00657
Complexity Summary
State Equations 2291
Optimal Time-Step 0.00538 ms
Relative Complexity 773.33 HH
Model Size
Sections 161
Compartments 227
State Equations 2291
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00538 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 773.33 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.50 %
Max. Stable Time-Step Benchmark Run Time 2080.02 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18638 Hz
CVODE Steps Per AP 67
CVODE Benchmark Run Time 528.19 HH
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