Layer 2/3 Burst Non-accommodating Neurogliaform Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform, biophysical, burst non-accommodating neurogliaform cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000322
bNAC219_L23_NGC_025b2126a1_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000322
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.76 mV
Rheobase Current Interval (0.02197, 0.02335] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0223 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop -0.0974 mV
AP 1 Steady State Amplitude Change 1.4607 mV
AP 1 Amplitude 50.4962 mV
AP 1 Width at Half Height 1.1300 ms
AP 1 Width (Peak To Trough) 7.7200 ms
AP 1 Rate of Change Peak to Trough -7.4149 mV/ms
AP 1 AHP Depth 6.7465 mV
AP2 Amplitude 50.5936 mV
AP2 Width at Half Height 1.1400 ms
AP 2 Width (Peak to Trough) 7.7800 ms
AP 2 Rate of Change Peak to Trough -7.3519 mV/ms
AP 2 AHP Depth 6.6043 mV
AP 1-2 Amplitude Change Percent 0.1929 %
AP 1-2 Half Width Change Percent 0.8850 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.8488 %
AP 1-2 AHP Depth Percent Change -2.1078 %
Input Resistance 485.5222 MΩ
AP 1 Delay Mean 58.8500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 106.5400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 51.7100 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0846 %/ms
Accommodation at Steady State Mean -70.3328 %
Accommodation Rate Mean at Steady State 188.3246 ms
ISI CV 4.0988
ISI Median 129.5850 ms
ISI Burst Mean Change 16.8589 %
Spike Rate (Strong Stimulation) 17.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 20.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.3900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.8850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2107.7600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 107.8539 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5040.39 µm2
Number of Stems 6.0
Number of Bifurcations 57.0
Number of Branches 119.0
Overall Width 238.021 µm
Overall Height 222.311 µm
Overall Depth 200.87 µm
Average Diameter 0.686537 µm
Total Length 5490.8 µm
Total Surface 9591.83 µm2
Total Volume 2849.61 µm3
Max Euclidean Distance 210.225 µm
Max Path Distance 289.607 µm
Max Branch Order 6.0
Average Contraction 0.967899
Total Fragmentation 1382.0
Partition Asymmetry 0.314716
Average Rall's Ratio 1.42675
Average Bifurcation Angle Local 43.6743 °
Average Bifurcation Angle Remote 58.5132 °
Fractal Dimension 1.00507
Complexity Summary
Relative Complexity 580.26 HH
State Equations 2881
Optimal Time-Step 0.00771 ms
Model Size
Sections 120
Compartments 286
State Equations 2881
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14427 Hz
CVODE Steps Per AP 229
CVODE Benchmark Run Time 580.26 HH
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