Layer 2/3 Burst Non-accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000317
bNAC219_L23_NBC_01d2e3caa6_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000317
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.37 mV
Rheobase Current Interval (0.04967, 0.05127] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0293 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 0.2203 mV
AP 1 Steady State Amplitude Change 3.2300 mV
AP 1 Amplitude 57.3246 mV
AP 1 Width at Half Height 0.8100 ms
AP 1 Width (Peak To Trough) 5.1900 ms
AP 1 Rate of Change Peak to Trough -13.4370 mV/ms
AP 1 AHP Depth 12.4136 mV
AP2 Amplitude 57.1043 mV
AP2 Width at Half Height 0.8200 ms
AP 2 Width (Peak to Trough) 5.3600 ms
AP 2 Rate of Change Peak to Trough -12.9998 mV/ms
AP 2 AHP Depth 12.5745 mV
AP 1-2 Amplitude Change Percent -0.3843 %
AP 1-2 Half Width Change Percent 1.2346 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.2541 %
AP 1-2 AHP Depth Percent Change 1.2964 %
Input Resistance 332.7971 MΩ
AP 1 Delay Mean 30.8700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 67.3000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 37.9000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -28.5714 %
Steady State Accommodation Mean -42.8571 %
Accommodation Rate to Steady State -0.1179 %/ms
Accommodation at Steady State Mean -68.7109 %
Accommodation Rate Mean at Steady State 179.3015 ms
ISI CV 4.4919
ISI Median 90.1600 ms
ISI Burst Mean Change 8.0703 %
Spike Rate (Strong Stimulation) 36.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.0100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.4200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.8800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2049.2600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 12045.8 µm2
Number of Stems 11.0
Number of Bifurcations 18.0
Number of Branches 46.0
Overall Width 207.958 µm
Overall Height 300.479 µm
Overall Depth 207.07 µm
Average Diameter 1.12385 µm
Total Length 3209.43 µm
Total Surface 11109.8 µm2
Total Volume 6027.0 µm3
Max Euclidean Distance 218.328 µm
Max Path Distance 262.904 µm
Max Branch Order 4.0
Average Contraction 0.927175
Total Fragmentation 1592.0
Partition Asymmetry 0.32963
Average Rall's Ratio 1.46154
Average Bifurcation Angle Local 29.4413 °
Average Bifurcation Angle Remote 78.0001 °
Fractal Dimension 1.01213
Complexity Summary
State Equations 1631
Optimal Time-Step 0.00784 ms
Relative Complexity 368.68 HH
Model Size
Sections 47
Compartments 161
State Equations 1631
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00784 ms
Optimal Time-Step Error 0.61 %
Optimal Time-Step Benchmark Run Time 368.68 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.19 %
Max. Stable Time-Step Benchmark Run Time 722.82 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12676 Hz
CVODE Steps Per AP 359
CVODE Benchmark Run Time 309.32 HH
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