Layer 2/3 Burst Non-accommodating Martinotti Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000313
bNAC219_L23_MC_44b474bb8f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000313
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.35 mV
Rheobase Current Interval (0.01648, 0.01740] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0180 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.2346 mV
AP 1 Steady State Amplitude Change 1.6072 mV
AP 1 Amplitude 58.2714 mV
AP 1 Width at Half Height 0.8900 ms
AP 1 Width (Peak To Trough) 6.0800 ms
AP 1 Rate of Change Peak to Trough -10.7632 mV/ms
AP 1 AHP Depth 7.1691 mV
AP2 Amplitude 58.0368 mV
AP2 Width at Half Height 0.8900 ms
AP 2 Width (Peak to Trough) 6.3900 ms
AP 2 Rate of Change Peak to Trough -10.2327 mV/ms
AP 2 AHP Depth 7.3505 mV
AP 1-2 Amplitude Change Percent -0.4026 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.9287 %
AP 1-2 AHP Depth Percent Change 2.5301 %
Input Resistance 646.3063 MΩ
AP 1 Delay Mean 56.7200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 106.0200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 51.9650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0758 %/ms
Accommodation at Steady State Mean -64.6124 %
Accommodation Rate Mean at Steady State 214.9360 ms
ISI CV 4.5453
ISI Median 115.6000 ms
ISI Burst Mean Change 10.8114 %
Spike Rate (Strong Stimulation) 19.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 20.1000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.7200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.4700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2067.8100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 116.5612 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2903.43 µm2
Number of Stems 6.0
Number of Bifurcations 43.0
Number of Branches 91.0
Overall Width 257.526 µm
Overall Height 336.343 µm
Overall Depth 143.67 µm
Average Diameter 0.722352 µm
Total Length 3745.57 µm
Total Surface 7521.79 µm2
Total Volume 2125.93 µm3
Max Euclidean Distance 294.798 µm
Max Path Distance 301.466 µm
Max Branch Order 7.0
Average Contraction 0.981605
Total Fragmentation 1299.0
Partition Asymmetry 0.506138
Average Rall's Ratio 1.13679
Average Bifurcation Angle Local 30.8114 °
Average Bifurcation Angle Remote 46.2445 °
Fractal Dimension 1.00294
Complexity Summary
State Equations 1961
Optimal Time-Step 0.00768 ms
Relative Complexity 473.22 HH
Model Size
Sections 92
Compartments 194
State Equations 1961
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 473.22 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.13 %
Max. Stable Time-Step Benchmark Run Time 907.72 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13789 Hz
CVODE Steps Per AP 345
CVODE Benchmark Run Time 411.71 HH
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