Layer 2/3 Burst Non-accommodating Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000310
bNAC219_L23_LBC_b35128281c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000310
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.93 mV
Rheobase Current Interval (0.02197, 0.02289] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0200 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.1239 mV
AP 1 Steady State Amplitude Change 1.5556 mV
AP 1 Amplitude 63.9738 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 3.1600 ms
AP 1 Rate of Change Peak to Trough -25.1611 mV/ms
AP 1 AHP Depth 15.5353 mV
AP2 Amplitude 64.0976 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 3.1700 ms
AP 2 Rate of Change Peak to Trough -25.0708 mV/ms
AP 2 AHP Depth 15.3768 mV
AP 1-2 Amplitude Change Percent 0.1936 %
AP 1-2 Half Width Change Percent 1.5152 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3589 %
AP 1-2 AHP Depth Percent Change -1.0203 %
Input Resistance 519.1587 MΩ
AP 1 Delay Mean 43.1400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 92.5600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 51.7950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0660 %/ms
Accommodation at Steady State Mean -63.9460 %
Accommodation Rate Mean at Steady State 215.7377 ms
ISI CV 4.6852
ISI Median 113.7800 ms
ISI Burst Mean Change 9.6115 %
Spike Rate (Strong Stimulation) 19.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.6000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 34.1500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.2600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2079.5300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4363.56 µm2
Number of Stems 8.0
Number of Bifurcations 12.0
Number of Branches 31.0
Overall Width 393.633 µm
Overall Height 481.787 µm
Overall Depth 258.58 µm
Average Diameter 0.771216 µm
Total Length 3523.46 µm
Total Surface 7123.46 µm2
Total Volume 2372.55 µm3
Max Euclidean Distance 354.515 µm
Max Path Distance 468.621 µm
Max Branch Order 3.0
Average Contraction 0.953831
Total Fragmentation 943.0
Partition Asymmetry 0.433333
Average Rall's Ratio 0.854286
Average Bifurcation Angle Local 28.6716 °
Average Bifurcation Angle Remote 49.7203 °
Fractal Dimension 1.00877
Complexity Summary
State Equations 1701
Optimal Time-Step 0.00776 ms
Relative Complexity 395.94 HH
Model Size
Sections 32
Compartments 168
State Equations 1701
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00776 ms
Optimal Time-Step Error 0.35 %
Optimal Time-Step Benchmark Run Time 395.94 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.11 %
Max. Stable Time-Step Benchmark Run Time 767.97 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14702 Hz
CVODE Steps Per AP 343
CVODE Benchmark Run Time 366.33 HH
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