Layer 2/3 Burst Non-accommodating Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000307
bNAC219_L23_LBC_91044b50b3_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000307
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.73 mV
Rheobase Current Interval (0.02197, 0.02289] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0133 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.2595 mV
AP 1 Steady State Amplitude Change 2.9267 mV
AP 1 Amplitude 65.3033 mV
AP 1 Width at Half Height 0.7200 ms
AP 1 Width (Peak To Trough) 4.3500 ms
AP 1 Rate of Change Peak to Trough -18.9112 mV/ms
AP 1 AHP Depth 16.9602 mV
AP2 Amplitude 65.0438 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 4.3800 ms
AP 2 Rate of Change Peak to Trough -18.7646 mV/ms
AP 2 AHP Depth 17.1453 mV
AP 1-2 Amplitude Change Percent -0.3974 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.7748 %
AP 1-2 AHP Depth Percent Change 1.0910 %
Input Resistance 708.3407 MΩ
AP 1 Delay Mean 29.5300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 69.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 42.1650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1126 %/ms
Accommodation at Steady State Mean -69.8523 %
Accommodation Rate Mean at Steady State 172.1095 ms
ISI CV 4.3591
ISI Median 103.8050 ms
ISI Burst Mean Change 9.7761 %
Spike Rate (Strong Stimulation) 25.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.5400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.6800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.7250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2041.3900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3346.75 µm2
Number of Stems 7.0
Number of Bifurcations 22.0
Number of Branches 50.0
Overall Width 136.287 µm
Overall Height 423.182 µm
Overall Depth 108.41 µm
Average Diameter 0.719584 µm
Total Length 2567.81 µm
Total Surface 5078.63 µm2
Total Volume 1690.22 µm3
Max Euclidean Distance 365.507 µm
Max Path Distance 374.201 µm
Max Branch Order 9.0
Average Contraction 0.981703
Total Fragmentation 792.0
Partition Asymmetry 0.590043
Average Rall's Ratio 1.28333
Average Bifurcation Angle Local 31.467 °
Average Bifurcation Angle Remote 42.6208 °
Fractal Dimension 1.00302
Complexity Summary
State Equations 1351
Optimal Time-Step 0.00778 ms
Relative Complexity 314.37 HH
Model Size
Sections 51
Compartments 133
State Equations 1351
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00778 ms
Optimal Time-Step Error 0.32 %
Optimal Time-Step Benchmark Run Time 314.37 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.74 %
Max. Stable Time-Step Benchmark Run Time 611.49 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13428 Hz
CVODE Steps Per AP 461
CVODE Benchmark Run Time 290.16 HH
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