Layer 2/3 Burst Non-accommodating Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: burst non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000305
bNAC219_L23_DBC_c9af6970b4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000305
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.98 mV
Rheobase Current Interval (0.02060, 0.02129] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0162 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.1196 mV
AP 1 Steady State Amplitude Change 2.9112 mV
AP 1 Amplitude 68.2487 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 2.9800 ms
AP 1 Rate of Change Peak to Trough -29.1360 mV/ms
AP 1 AHP Depth 18.5766 mV
AP2 Amplitude 68.1291 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 2.9800 ms
AP 2 Rate of Change Peak to Trough -29.1343 mV/ms
AP 2 AHP Depth 18.6910 mV
AP 1-2 Amplitude Change Percent -0.1752 %
AP 1-2 Half Width Change Percent -1.6949 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.0059 %
AP 1-2 AHP Depth Percent Change 0.6159 %
Input Resistance 633.8675 MΩ
AP 1 Delay Mean 37.4100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 80.3300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 44.9600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1127 %/ms
Accommodation at Steady State Mean -66.2072 %
Accommodation Rate Mean at Steady State 198.0503 ms
ISI CV 4.5498
ISI Median 103.5800 ms
ISI Burst Mean Change 9.5061 %
Spike Rate (Strong Stimulation) 24.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.6900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 29.1100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.9850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2069.9800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4272.46 µm2
Number of Stems 8.0
Number of Bifurcations 20.0
Number of Branches 47.0
Overall Width 314.415 µm
Overall Height 492.706 µm
Overall Depth 212.42 µm
Average Diameter 0.496674 µm
Total Length 3916.32 µm
Total Surface 6199.1 µm2
Total Volume 2159.77 µm3
Max Euclidean Distance 404.079 µm
Max Path Distance 486.222 µm
Max Branch Order 5.0
Average Contraction 0.953278
Total Fragmentation 4014.0
Partition Asymmetry 0.483333
Average Rall's Ratio 0.781818
Average Bifurcation Angle Local 31.1902 °
Average Bifurcation Angle Remote 51.8964 °
Fractal Dimension 1.00985
Complexity Summary
State Equations 2021
Optimal Time-Step 0.00784 ms
Relative Complexity 469.16 HH
Model Size
Sections 48
Compartments 200
State Equations 2021
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00784 ms
Optimal Time-Step Error 0.48 %
Optimal Time-Step Benchmark Run Time 469.16 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.63 %
Max. Stable Time-Step Benchmark Run Time 919.01 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13628 Hz
CVODE Steps Per AP 551
CVODE Benchmark Run Time 462.66 HH
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