Layer 1 Burst Non-accommodating Small Axon Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon, biophysical, burst non-accommodating small axon cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000290
bNAC219_L1_SLAC_bb26216f9f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000290
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.02 mV
Rheobase Current Interval (0.01648, 0.01694] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0088 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop -0.0945 mV
AP 1 Steady State Amplitude Change 1.1827 mV
AP 1 Amplitude 79.0508 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 3.0500 ms
AP 1 Rate of Change Peak to Trough -34.8855 mV/ms
AP 1 AHP Depth 27.3501 mV
AP2 Amplitude 79.1454 mV
AP2 Width at Half Height 0.5000 ms
AP 2 Width (Peak to Trough) 3.0400 ms
AP 2 Rate of Change Peak to Trough -34.8927 mV/ms
AP 2 AHP Depth 26.9286 mV
AP 1-2 Amplitude Change Percent 0.1196 %
AP 1-2 Half Width Change Percent 2.0408 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.0206 %
AP 1-2 AHP Depth Percent Change -1.5411 %
Input Resistance 921.6371 MΩ
AP 1 Delay Mean 24.2800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 61.6200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 45.3650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0601 %/ms
Accommodation at Steady State Mean -82.2126 %
Accommodation Rate Mean at Steady State 119.9547 ms
ISI CV 3.6290
ISI Median 152.8150 ms
ISI Burst Mean Change 42.9834 %
Spike Rate (Strong Stimulation) 13.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.7300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.1200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.6200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2048.9800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 93.6662 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4018.63 µm2
Number of Stems 6.0
Number of Bifurcations 34.0
Number of Branches 73.0
Overall Width 152.038 µm
Overall Height 255.848 µm
Overall Depth 89.54 µm
Average Diameter 0.5798 µm
Total Length 1801.87 µm
Total Surface 2808.83 µm2
Total Volume 1452.15 µm3
Max Euclidean Distance 175.511 µm
Max Path Distance 215.598 µm
Max Branch Order 7.0
Average Contraction 0.963329
Total Fragmentation 849.0
Partition Asymmetry 0.552279
Average Rall's Ratio 1.35333
Average Bifurcation Angle Local 73.3362 °
Average Bifurcation Angle Remote 86.1079 °
Fractal Dimension 1.00669
Complexity Summary
Relative Complexity 251.61 HH
State Equations 1071
Optimal Time-Step 0.00776 ms
Model Size
Sections 73
Compartments 105
State Equations 1071
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15131 Hz
CVODE Steps Per AP 466
CVODE Benchmark Run Time 251.61 HH
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