Layer 1 Burst Non-accommodating Small Axon Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000289
bNAC219_L1_SLAC_9f043bb71a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000289
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.04 mV
Rheobase Current Interval (0.02747, 0.02838] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0149 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.4372 mV
AP 1 Steady State Amplitude Change 3.7365 mV
AP 1 Amplitude 61.5382 mV
AP 1 Width at Half Height 0.7800 ms
AP 1 Width (Peak To Trough) 4.2300 ms
AP 1 Rate of Change Peak to Trough -18.6901 mV/ms
AP 1 AHP Depth 17.5209 mV
AP2 Amplitude 61.1010 mV
AP2 Width at Half Height 0.7700 ms
AP 2 Width (Peak to Trough) 4.2800 ms
AP 2 Rate of Change Peak to Trough -18.4369 mV/ms
AP 2 AHP Depth 17.8088 mV
AP 1-2 Amplitude Change Percent -0.7105 %
AP 1-2 Half Width Change Percent -1.2821 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.3549 %
AP 1-2 AHP Depth Percent Change 1.6430 %
Input Resistance 610.2407 MΩ
AP 1 Delay Mean 23.4200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 57.4000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 36.9750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1825 %/ms
Accommodation at Steady State Mean -79.1821 %
Accommodation Rate Mean at Steady State 126.2896 ms
ISI CV 3.8673
ISI Median 114.9150 ms
ISI Burst Mean Change 17.6280 %
Spike Rate (Strong Stimulation) 24.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.4900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 24.7600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.9550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2045.1400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6290.69 µm2
Number of Stems 5.0
Number of Bifurcations 20.0
Number of Branches 44.0
Overall Width 182.019 µm
Overall Height 382.242 µm
Overall Depth 123.93 µm
Average Diameter 0.925246 µm
Total Length 1847.7 µm
Total Surface 4940.56 µm2
Total Volume 2738.58 µm3
Max Euclidean Distance 356.664 µm
Max Path Distance 430.089 µm
Max Branch Order 5.0
Average Contraction 0.970925
Total Fragmentation 829.0
Partition Asymmetry 0.404762
Average Rall's Ratio 2.53071
Average Bifurcation Angle Local 34.5876 °
Average Bifurcation Angle Remote 72.9537 °
Fractal Dimension 1.00449
Complexity Summary
State Equations 871
Optimal Time-Step 0.00793 ms
Relative Complexity 192.61 HH
Model Size
Sections 43
Compartments 85
State Equations 871
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00793 ms
Optimal Time-Step Error 0.24 %
Optimal Time-Step Benchmark Run Time 192.61 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.46 %
Max. Stable Time-Step Benchmark Run Time 381.91 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14259 Hz
CVODE Steps Per AP 387
CVODE Benchmark Run Time 182.17 HH
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