Layer 1 Burst Non-accommodating Small Axon Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000288
bNAC219_L1_SLAC_8a5944f8ac_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000288
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.11 mV
Rheobase Current Interval (0.01167, 0.01190] nA
Threshold Current Interval (0.00000, 0.05859] nA
Bias Current (to -80.00 mV) -0.0055 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 0.3436 mV
AP 1 Steady State Amplitude Change 4.0137 mV
AP 1 Amplitude 79.8173 mV
AP 1 Width at Half Height 0.4500 ms
AP 1 Width (Peak To Trough) 2.8300 ms
AP 1 Rate of Change Peak to Trough -37.5405 mV/ms
AP 1 AHP Depth 26.4223 mV
AP2 Amplitude 79.4737 mV
AP2 Width at Half Height 0.4400 ms
AP 2 Width (Peak to Trough) 2.8300 ms
AP 2 Rate of Change Peak to Trough -37.4269 mV/ms
AP 2 AHP Depth 26.4444 mV
AP 1-2 Amplitude Change Percent -0.4304 %
AP 1-2 Half Width Change Percent -2.2222 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3026 %
AP 1-2 AHP Depth Percent Change 0.0837 %
Input Resistance 1585.9013 MΩ
AP 1 Delay Mean 15.4400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 41.4000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 32.4750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1818 %/ms
Accommodation at Steady State Mean -88.2250 %
Accommodation Rate Mean at Steady State 85.5050 ms
ISI CV 3.5993
ISI Median 132.3100 ms
ISI Burst Mean Change 50.1926 %
Spike Rate (Strong Stimulation) 17.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.6500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.3400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.4800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2039.5600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2169.67 µm2
Number of Stems 4.0
Number of Bifurcations 10.0
Number of Branches 23.0
Overall Width 125.743 µm
Overall Height 154.808 µm
Overall Depth 63.14 µm
Average Diameter 0.794314 µm
Total Length 937.774 µm
Total Surface 1338.22 µm2
Total Volume 704.331 µm3
Max Euclidean Distance 98.9375 µm
Max Path Distance 141.145 µm
Max Branch Order 4.0
Average Contraction 0.95548
Total Fragmentation 323.0
Partition Asymmetry 0.6
Average Rall's Ratio 0.939
Average Bifurcation Angle Local 57.4571 °
Average Bifurcation Angle Remote 65.5756 °
Fractal Dimension 1.00838
Complexity Summary
State Equations 521
Optimal Time-Step 0.00536 ms
Relative Complexity 171.20 HH
Model Size
Sections 24
Compartments 50
State Equations 521
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00536 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 171.20 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.53 %
Max. Stable Time-Step Benchmark Run Time 458.63 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15006 Hz
CVODE Steps Per AP 517
CVODE Benchmark Run Time 121.70 HH
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