Layer 1 Burst Non-accommodating Small Axon Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon, biophysical, burst non-accommodating small axon cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000287
bNAC219_L1_SLAC_1aa0a09b13_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000287
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.04 mV
Rheobase Current Interval (0.01648, 0.01717] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0094 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.0852 mV
AP 1 Steady State Amplitude Change 2.7655 mV
AP 1 Amplitude 63.5336 mV
AP 1 Width at Half Height 0.7900 ms
AP 1 Width (Peak To Trough) 4.3700 ms
AP 1 Rate of Change Peak to Trough -18.7424 mV/ms
AP 1 AHP Depth 18.3708 mV
AP2 Amplitude 63.4485 mV
AP2 Width at Half Height 0.7900 ms
AP 2 Width (Peak to Trough) 4.4100 ms
AP 2 Rate of Change Peak to Trough -18.5625 mV/ms
AP 2 AHP Depth 18.4121 mV
AP 1-2 Amplitude Change Percent -0.1341 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.9601 %
AP 1-2 AHP Depth Percent Change 0.2250 %
Input Resistance 970.0723 MΩ
AP 1 Delay Mean 28.2500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 68.9700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 43.7500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.0486 %/ms
Accommodation at Steady State Mean -73.8317 %
Accommodation Rate Mean at Steady State 151.3448 ms
ISI CV 4.1449
ISI Median 118.6250 ms
ISI Burst Mean Change 14.8821 %
Spike Rate (Strong Stimulation) 21.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.3400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 29.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.5700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2035.2000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3135.83 µm2
Number of Stems 6.0
Number of Bifurcations 28.0
Number of Branches 61.0
Overall Width 206.101 µm
Overall Height 184.655 µm
Overall Depth 105.91 µm
Average Diameter 0.712791 µm
Total Length 1913.85 µm
Total Surface 3559.16 µm2
Total Volume 1592.72 µm3
Max Euclidean Distance 209.516 µm
Max Path Distance 242.511 µm
Max Branch Order 6.0
Average Contraction 0.974656
Total Fragmentation 1032.0
Partition Asymmetry 0.463889
Average Rall's Ratio 1.36395
Average Bifurcation Angle Local 57.9485 °
Average Bifurcation Angle Remote 65.639 °
Fractal Dimension 1.00414
Complexity Summary
Relative Complexity 213.44 HH
State Equations 1041
Optimal Time-Step 0.00779 ms
Model Size
Sections 62
Compartments 102
State Equations 1041
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13863 Hz
CVODE Steps Per AP 460
CVODE Benchmark Run Time 213.44 HH
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