Layer 1 Burst Non-accommodating Neurogliaform Cell with dense axonal arborization (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000282
bNAC219_L1_NGCDA_095997ce92_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000282
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.53 mV
Rheobase Current Interval (0.01373, 0.01419] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0065 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 0.0226 mV
AP 1 Steady State Amplitude Change 1.7846 mV
AP 1 Amplitude 84.1276 mV
AP 1 Width at Half Height 0.4200 ms
AP 1 Width (Peak To Trough) 2.4800 ms
AP 1 Rate of Change Peak to Trough -45.5127 mV/ms
AP 1 AHP Depth 28.7438 mV
AP2 Amplitude 84.1050 mV
AP2 Width at Half Height 0.4200 ms
AP 2 Width (Peak to Trough) 2.4400 ms
AP 2 Rate of Change Peak to Trough -46.1205 mV/ms
AP 2 AHP Depth 28.4291 mV
AP 1-2 Amplitude Change Percent -0.0269 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.3356 %
AP 1-2 AHP Depth Percent Change -1.0950 %
Input Resistance 1222.8254 MΩ
AP 1 Delay Mean 16.0800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 41.5200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 44.7350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0909 %/ms
Accommodation at Steady State Mean -88.5505 %
Accommodation Rate Mean at Steady State 101.4026 ms
ISI CV 3.5153
ISI Median 154.7350 ms
ISI Burst Mean Change 151.6903 %
Spike Rate (Strong Stimulation) 12.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.7500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.1200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.5200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2042.5300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 104.1804 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3158.46 µm2
Number of Stems 6.0
Number of Bifurcations 28.0
Number of Branches 61.0
Overall Width 101.394 µm
Overall Height 152.853 µm
Overall Depth 53.28 µm
Average Diameter 0.672232 µm
Total Length 1218.44 µm
Total Surface 1523.88 µm2
Total Volume 942.765 µm3
Max Euclidean Distance 107.497 µm
Max Path Distance 184.192 µm
Max Branch Order 6.0
Average Contraction 0.981524
Total Fragmentation 382.0
Partition Asymmetry 0.429762
Average Rall's Ratio 1.585
Average Bifurcation Angle Local 81.3657 °
Average Bifurcation Angle Remote 78.2076 °
Fractal Dimension 1.00473
Complexity Summary
State Equations 821
Optimal Time-Step 0.00778 ms
Relative Complexity 186.03 HH
Model Size
Sections 60
Compartments 80
State Equations 821
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00778 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 186.03 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.74 %
Max. Stable Time-Step Benchmark Run Time 361.54 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15184 Hz
CVODE Steps Per AP 443
CVODE Benchmark Run Time 186.52 HH
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