Layer 1 Burst Non-accommodating Horizontal Axon Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, horizontal axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000279
bNAC219_L1_HAC_dfd993e67b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000279
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.48 mV
Rheobase Current Interval (0.02289, 0.02403] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0147 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -3.8969 mV
AP 1 Steady State Amplitude Change -0.3773 mV
AP 1 Amplitude 47.6983 mV
AP 1 Width at Half Height 0.9300 ms
AP 1 Width (Peak To Trough) 6.3800 ms
AP 1 Rate of Change Peak to Trough -10.1772 mV/ms
AP 1 AHP Depth 17.2322 mV
AP2 Amplitude 51.5952 mV
AP2 Width at Half Height 0.8600 ms
AP 2 Width (Peak to Trough) 6.1400 ms
AP 2 Rate of Change Peak to Trough -11.3991 mV/ms
AP 2 AHP Depth 18.3953 mV
AP 1-2 Amplitude Change Percent 8.1700 %
AP 1-2 Half Width Change Percent -7.5269 %
AP 1-2 Rate of Change Peak to Trough Percent Change 12.0065 %
AP 1-2 AHP Depth Percent Change 6.7497 %
Input Resistance 658.7122 MΩ
AP 1 Delay Mean 41.1100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 88.9700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.0600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0649 %/ms
Accommodation at Steady State Mean -62.5415 %
Accommodation Rate Mean at Steady State 203.2933 ms
ISI CV 4.9361
ISI Median 112.2300 ms
ISI Burst Mean Change 21.7300 %
Spike Rate (Strong Stimulation) 24.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 15.4100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 36.0800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 21.2250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2074.4400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4315.95 µm2
Number of Stems 6.0
Number of Bifurcations 25.0
Number of Branches 55.0
Overall Width 151.726 µm
Overall Height 227.081 µm
Overall Depth 74.19 µm
Average Diameter 1.04431 µm
Total Length 1883.8 µm
Total Surface 6026.37 µm2
Total Volume 2499.36 µm3
Max Euclidean Distance 177.286 µm
Max Path Distance 195.269 µm
Max Branch Order 7.0
Average Contraction 0.924634
Total Fragmentation 1375.0
Partition Asymmetry 0.462476
Average Rall's Ratio 1.89423
Average Bifurcation Angle Local 31.4223 °
Average Bifurcation Angle Remote 56.9387 °
Fractal Dimension 1.0156
Complexity Summary
State Equations 1001
Optimal Time-Step 0.00513 ms
Relative Complexity 340.83 HH
Model Size
Sections 56
Compartments 98
State Equations 1001
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00513 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 340.83 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.87 %
Max. Stable Time-Step Benchmark Run Time 873.83 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17203 Hz
CVODE Steps Per AP 253
CVODE Benchmark Run Time 226.85 HH
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