Layer 1 Burst Non-accommodating Descending Axon Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000275
bNAC219_L1_DAC_a9ae5cbbf5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000275
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.26 mV
Rheobase Current Interval (0.02747, 0.02815] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0119 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.1987 mV
AP 1 Steady State Amplitude Change 5.1977 mV
AP 1 Amplitude 63.7315 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 4.0900 ms
AP 1 Rate of Change Peak to Trough -19.9729 mV/ms
AP 1 AHP Depth 17.9578 mV
AP2 Amplitude 63.5328 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 4.1400 ms
AP 2 Rate of Change Peak to Trough -19.7053 mV/ms
AP 2 AHP Depth 18.0471 mV
AP 1-2 Amplitude Change Percent -0.3117 %
AP 1-2 Half Width Change Percent 1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.3400 %
AP 1-2 AHP Depth Percent Change 0.4974 %
Input Resistance 746.2171 MΩ
AP 1 Delay Mean 18.8800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 47.7500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.9250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1015 %/ms
Accommodation at Steady State Mean -80.8968 %
Accommodation Rate Mean at Steady State 111.9741 ms
ISI CV 3.9793
ISI Median 99.5600 ms
ISI Burst Mean Change 14.2362 %
Spike Rate (Strong Stimulation) 42.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.1900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 22.0600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.3650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2017.4000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5525.04 µm2
Number of Stems 7.0
Number of Bifurcations 20.0
Number of Branches 46.0
Overall Width 87.5863 µm
Overall Height 123.267 µm
Overall Depth 78.98 µm
Average Diameter 0.985905 µm
Total Length 1407.67 µm
Total Surface 3936.39 µm2
Total Volume 2381.39 µm3
Max Euclidean Distance 102.955 µm
Max Path Distance 143.598 µm
Max Branch Order 4.0
Average Contraction 0.910062
Total Fragmentation 963.0
Partition Asymmetry 0.416667
Average Rall's Ratio 0.977647
Average Bifurcation Angle Local 22.409 °
Average Bifurcation Angle Remote 91.5189 °
Fractal Dimension 1.01856
Complexity Summary
State Equations 771
Optimal Time-Step 0.00771 ms
Relative Complexity 181.30 HH
Model Size
Sections 47
Compartments 75
State Equations 771
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.40 %
Optimal Time-Step Benchmark Run Time 181.30 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.64 %
Max. Stable Time-Step Benchmark Run Time 349.40 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13412 Hz
CVODE Steps Per AP 385
CVODE Benchmark Run Time 158.73 HH
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