Layer 1 Burst Non-accommodating Descending Axon Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: burst non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000274
bNAC219_L1_DAC_81e928d216_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000274
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.30 mV
Rheobase Current Interval (0.01373, 0.01465] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0127 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.0808 mV
AP 1 Steady State Amplitude Change 1.3914 mV
AP 1 Amplitude 56.6003 mV
AP 1 Width at Half Height 0.9600 ms
AP 1 Width (Peak To Trough) 6.6300 ms
AP 1 Rate of Change Peak to Trough -10.3891 mV/ms
AP 1 AHP Depth 12.2792 mV
AP2 Amplitude 56.5195 mV
AP2 Width at Half Height 0.9500 ms
AP 2 Width (Peak to Trough) 6.8900 ms
AP 2 Rate of Change Peak to Trough -9.9969 mV/ms
AP 2 AHP Depth 12.3594 mV
AP 1-2 Amplitude Change Percent -0.1428 %
AP 1-2 Half Width Change Percent -1.0417 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.7745 %
AP 1-2 AHP Depth Percent Change 0.6529 %
Input Resistance 786.0872 MΩ
AP 1 Delay Mean 52.1100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 111.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 63.5650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -60.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0779 %/ms
Accommodation at Steady State Mean -62.7521 %
Accommodation Rate Mean at Steady State 218.0616 ms
ISI CV 4.5718
ISI Median 136.2300 ms
ISI Burst Mean Change 13.7357 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 18.8600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 42.9500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.2700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2071.2000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3038.57 µm2
Number of Stems 8.0
Number of Bifurcations 30.0
Number of Branches 67.0
Overall Width 196.107 µm
Overall Height 200.421 µm
Overall Depth 144.19 µm
Average Diameter 0.65489 µm
Total Length 3020.43 µm
Total Surface 5595.91 µm2
Total Volume 1890.61 µm3
Max Euclidean Distance 205.809 µm
Max Path Distance 231.609 µm
Max Branch Order 7.0
Average Contraction 0.946447
Total Fragmentation 1680.0
Partition Asymmetry 0.444545
Average Rall's Ratio 1.20889
Average Bifurcation Angle Local 38.191 °
Average Bifurcation Angle Remote 73.37 °
Fractal Dimension 1.00931
Complexity Summary
State Equations 1581
Optimal Time-Step 0.00769 ms
Relative Complexity 368.98 HH
Model Size
Sections 68
Compartments 156
State Equations 1581
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00769 ms
Optimal Time-Step Error 0.06 %
Optimal Time-Step Benchmark Run Time 368.98 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.62 %
Max. Stable Time-Step Benchmark Run Time 708.86 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14853 Hz
CVODE Steps Per AP 320
CVODE Benchmark Run Time 336.69 HH
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