Layer 6 Burst Irregular Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000271
bIR215_L6_NBC_ebdeb060a6_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000271
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.94 mV
Rheobase Current Interval (0.20874, 0.21057] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -70.00 mV) 0.0432 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 9.5768 mV
AP 1 Steady State Amplitude Change 9.2908 mV
AP 1 Amplitude 86.1017 mV
AP 1 Width at Half Height 0.4200 ms
AP 1 Width (Peak To Trough) 2.5600 ms
AP 1 Rate of Change Peak to Trough -42.8668 mV/ms
AP 1 AHP Depth 23.6374 mV
AP2 Amplitude 76.5250 mV
AP2 Width at Half Height 0.4300 ms
AP 2 Width (Peak to Trough) 2.6000 ms
AP 2 Rate of Change Peak to Trough -39.0744 mV/ms
AP 2 AHP Depth 25.0684 mV
AP 1-2 Amplitude Change Percent -11.1226 %
AP 1-2 Half Width Change Percent 2.3810 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.8471 %
AP 1-2 AHP Depth Percent Change 6.0540 %
Input Resistance 203.5805 MΩ
AP 1 Delay Mean 5.0200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 44.2400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 87.2350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1395 %/ms
Accommodation at Steady State Mean -77.7686 %
Accommodation Rate Mean at Steady State 97.4398 ms
ISI CV 4.2189
ISI Median 171.3350 ms
ISI Burst Mean Change 244.8496 %
Spike Rate (Strong Stimulation) 14.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.0600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.8300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.0850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2220.3700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.2426 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 17060.0 µm2
Number of Stems 7.0
Number of Bifurcations 23.0
Number of Branches 52.0
Overall Width 401.907 µm
Overall Height 288.683 µm
Overall Depth 103.18 µm
Average Diameter 1.23029 µm
Total Length 2175.06 µm
Total Surface 7670.82 µm2
Total Volume 7409.24 µm3
Max Euclidean Distance 287.696 µm
Max Path Distance 332.693 µm
Max Branch Order 6.0
Average Contraction 0.954816
Total Fragmentation 1861.0
Partition Asymmetry 0.403382
Average Rall's Ratio 0.643684
Average Bifurcation Angle Local 37.8628 °
Average Bifurcation Angle Remote 69.8482 °
Fractal Dimension 1.00926
Complexity Summary
State Equations 1295
Optimal Time-Step 0.00790 ms
Relative Complexity 319.01 HH
Model Size
Sections 52
Compartments 116
State Equations 1295
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00790 ms
Optimal Time-Step Error 0.26 %
Optimal Time-Step Benchmark Run Time 319.01 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.13 %
Max. Stable Time-Step Benchmark Run Time 629.54 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16243 Hz
CVODE Steps Per AP 257
CVODE Benchmark Run Time 311.65 HH
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