Layer 6 Burst Irregular Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000269
bIR215_L6_NBC_a104961d30_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000269
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.73 mV
Rheobase Current Interval (0.16182, 0.16342] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0300 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 5.0807 mV
AP 1 Steady State Amplitude Change 6.8990 mV
AP 1 Amplitude 80.8208 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 2.2500 ms
AP 1 Rate of Change Peak to Trough -45.2169 mV/ms
AP 1 AHP Depth 20.9171 mV
AP2 Amplitude 75.7401 mV
AP2 Width at Half Height 0.4700 ms
AP 2 Width (Peak to Trough) 2.3000 ms
AP 2 Rate of Change Peak to Trough -41.9482 mV/ms
AP 2 AHP Depth 20.7407 mV
AP 1-2 Amplitude Change Percent -6.2864 %
AP 1-2 Half Width Change Percent 2.1739 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.2289 %
AP 1-2 AHP Depth Percent Change -0.8432 %
Input Resistance 0.9448 MΩ
AP 1 Delay Mean 7.1500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 35.6400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.6450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1419 %/ms
Accommodation at Steady State Mean -87.4572 %
Accommodation Rate Mean at Steady State 128.9247 ms
ISI CV 3.2595
ISI Median 121.2550 ms
ISI Burst Mean Change 15.1281 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.0700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.1350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2059.9100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.5812 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6007.87 µm2
Number of Stems 7.0
Number of Bifurcations 27.0
Number of Branches 60.0
Overall Width 379.262 µm
Overall Height 540.615 µm
Overall Depth 248.1 µm
Average Diameter 0.912917 µm
Total Length 4335.81 µm
Total Surface 11481.0 µm2
Total Volume 3941.78 µm3
Max Euclidean Distance 422.589 µm
Max Path Distance 448.976 µm
Max Branch Order 4.0
Average Contraction 0.979376
Total Fragmentation 1218.0
Partition Asymmetry 0.380658
Average Rall's Ratio 0.937857
Average Bifurcation Angle Local 43.9018 °
Average Bifurcation Angle Remote 49.3804 °
Fractal Dimension 1.00324
Complexity Summary
State Equations 2362
Optimal Time-Step 0.00771 ms
Relative Complexity 594.68 HH
Model Size
Sections 61
Compartments 213
State Equations 2362
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 594.68 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.40 %
Max. Stable Time-Step Benchmark Run Time 1145.85 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13253 Hz
CVODE Steps Per AP 624
CVODE Benchmark Run Time 587.75 HH
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