Layer 6 Burst Irregular Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000267
bIR215_L6_NBC_5d97f161ff_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000267
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.49 mV
Rheobase Current Interval (0.15381, 0.15518] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0310 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 7.4378 mV
AP 1 Steady State Amplitude Change 8.3369 mV
AP 1 Amplitude 86.1917 mV
AP 1 Width at Half Height 0.4200 ms
AP 1 Width (Peak To Trough) 1.8900 ms
AP 1 Rate of Change Peak to Trough -57.7280 mV/ms
AP 1 AHP Depth 22.9142 mV
AP2 Amplitude 78.7539 mV
AP2 Width at Half Height 0.4100 ms
AP 2 Width (Peak to Trough) 1.8800 ms
AP 2 Rate of Change Peak to Trough -55.1199 mV/ms
AP 2 AHP Depth 24.8714 mV
AP 1-2 Amplitude Change Percent -8.6294 %
AP 1-2 Half Width Change Percent -2.3810 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.5179 %
AP 1-2 AHP Depth Percent Change 8.5418 %
Input Resistance 220.4717 MΩ
AP 1 Delay Mean 5.3600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 34.0200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 31.1700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1935 %/ms
Accommodation at Steady State Mean -87.9199 %
Accommodation Rate Mean at Steady State 121.5318 ms
ISI CV 3.2395
ISI Median 127.5000 ms
ISI Burst Mean Change 17.5157 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.6900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.1900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.6200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2097.4300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 79.3382 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7922.87 µm2
Number of Stems 6.0
Number of Bifurcations 37.0
Number of Branches 79.0
Overall Width 438.753 µm
Overall Height 465.677 µm
Overall Depth 256.42 µm
Average Diameter 0.669312 µm
Total Length 5997.2 µm
Total Surface 9412.54 µm2
Total Volume 3708.03 µm3
Max Euclidean Distance 376.301 µm
Max Path Distance 412.96 µm
Max Branch Order 5.0
Average Contraction 0.97583
Total Fragmentation 1849.0
Partition Asymmetry 0.323895
Average Rall's Ratio 0.55
Average Bifurcation Angle Local 34.4198 °
Average Bifurcation Angle Remote 41.4119 °
Fractal Dimension 1.00419
Complexity Summary
State Equations 3319
Optimal Time-Step 0.00792 ms
Relative Complexity 854.48 HH
Model Size
Sections 80
Compartments 300
State Equations 3319
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00792 ms
Optimal Time-Step Error 0.28 %
Optimal Time-Step Benchmark Run Time 854.48 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.06 %
Max. Stable Time-Step Benchmark Run Time 1690.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17062 Hz
CVODE Steps Per AP 458
CVODE Benchmark Run Time 962.45 HH
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