Layer 6 Burst Irregular Martinotti Cell (3)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti, biophysical, burst irregular martinotti cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000264
bIR215_L6_MC_6ed36072e7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000264
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.77 mV
Rheobase Current Interval (0.11444, 0.11559] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0245 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 19.6818 mV
AP 1 Steady State Amplitude Change 25.2880 mV
AP 1 Amplitude 82.1970 mV
AP 1 Width at Half Height 0.4400 ms
AP 1 Width (Peak To Trough) 2.2600 ms
AP 1 Rate of Change Peak to Trough -45.6728 mV/ms
AP 1 AHP Depth 21.0236 mV
AP2 Amplitude 62.5152 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.7200 ms
AP 2 Rate of Change Peak to Trough -29.8930 mV/ms
AP 2 AHP Depth 18.7937 mV
AP 1-2 Amplitude Change Percent -23.9446 %
AP 1-2 Half Width Change Percent 29.5455 %
AP 1-2 Rate of Change Peak to Trough Percent Change -34.5497 %
AP 1-2 AHP Depth Percent Change -10.6064 %
Input Resistance 305.9239 MΩ
AP 1 Delay Mean 4.9100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 138.2300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 193.9750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0848 %/ms
Accommodation at Steady State Mean -44.7084 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 5.9367
ISI Median 236.8050 ms
ISI Burst Mean Change 90.9916 %
Spike Rate (Strong Stimulation) 14.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.9600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.0900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 21.0000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2278.3600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.5275 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5275.49 µm2
Number of Stems 6.0
Number of Bifurcations 53.0
Number of Branches 111.0
Overall Width 294.045 µm
Overall Height 471.847 µm
Overall Depth 226.69 µm
Average Diameter 0.395834 µm
Total Length 5869.6 µm
Total Surface 7742.93 µm2
Total Volume 2649.55 µm3
Max Euclidean Distance 379.573 µm
Max Path Distance 433.939 µm
Max Branch Order 10.0
Average Contraction 0.932137
Total Fragmentation 4196.0
Partition Asymmetry 0.382044
Average Rall's Ratio 0.707368
Average Bifurcation Angle Local 30.6116 °
Average Bifurcation Angle Remote 63.6924 °
Fractal Dimension 1.01549
Complexity Summary
Relative Complexity 1752.35 HH
State Equations 3187
Optimal Time-Step 0.01094 ms
Model Size
Sections 112
Compartments 288
State Equations 3187
Variable Time-Step Complexity
CVODE Steady State Step Frequency 21276 Hz
CVODE Steps Per AP 1884
CVODE Benchmark Run Time 1752.35 HH
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