Layer 6 Burst Irregular Martinotti Cell (2)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti, biophysical, burst irregular martinotti cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000263
bIR215_L6_MC_6c575906a7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000263
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.54 mV
Rheobase Current Interval (0.19592, 0.19775] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0344 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 5.6489 mV
AP 1 Steady State Amplitude Change 6.4893 mV
AP 1 Amplitude 80.8276 mV
AP 1 Width at Half Height 0.5000 ms
AP 1 Width (Peak To Trough) 2.3100 ms
AP 1 Rate of Change Peak to Trough -43.6187 mV/ms
AP 1 AHP Depth 19.9316 mV
AP2 Amplitude 75.1787 mV
AP2 Width at Half Height 0.4900 ms
AP 2 Width (Peak to Trough) 2.3800 ms
AP 2 Rate of Change Peak to Trough -40.0075 mV/ms
AP 2 AHP Depth 20.0392 mV
AP 1-2 Amplitude Change Percent -6.9888 %
AP 1-2 Half Width Change Percent -2.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.2790 %
AP 1-2 AHP Depth Percent Change 0.5397 %
Input Resistance 152.6883 MΩ
AP 1 Delay Mean 6.3600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 33.5800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.3850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1460 %/ms
Accommodation at Steady State Mean -89.1799 %
Accommodation Rate Mean at Steady State 122.1581 ms
ISI CV 3.2074
ISI Median 123.4000 ms
ISI Burst Mean Change 15.9074 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.9300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.1600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.5250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2075.7100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 83.2802 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6152.5 µm2
Number of Stems 5.0
Number of Bifurcations 45.0
Number of Branches 94.0
Overall Width 521.191 µm
Overall Height 581.744 µm
Overall Depth 228.97 µm
Average Diameter 0.714617 µm
Total Length 6147.04 µm
Total Surface 13077.0 µm2
Total Volume 4242.09 µm3
Max Euclidean Distance 392.565 µm
Max Path Distance 439.561 µm
Max Branch Order 9.0
Average Contraction 0.936686
Total Fragmentation 5007.0
Partition Asymmetry 0.512609
Average Rall's Ratio 1.49548
Average Bifurcation Angle Local 37.9498 °
Average Bifurcation Angle Remote 63.8135 °
Fractal Dimension 1.01302
Complexity Summary
Relative Complexity 917.68 HH
State Equations 3594
Optimal Time-Step 0.00779 ms
Model Size
Sections 95
Compartments 325
State Equations 3594
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16217 Hz
CVODE Steps Per AP 323
CVODE Benchmark Run Time 917.68 HH
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