Layer 6 Burst Irregular Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000262
bIR215_L6_MC_62cf39b45d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000262
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.66 mV
Rheobase Current Interval (0.20187, 0.20348] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0382 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 7.9490 mV
AP 1 Steady State Amplitude Change 8.8023 mV
AP 1 Amplitude 83.5649 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 2.5400 ms
AP 1 Rate of Change Peak to Trough -41.4994 mV/ms
AP 1 AHP Depth 21.8436 mV
AP2 Amplitude 75.6159 mV
AP2 Width at Half Height 0.4600 ms
AP 2 Width (Peak to Trough) 2.6200 ms
AP 2 Rate of Change Peak to Trough -37.1690 mV/ms
AP 2 AHP Depth 21.7670 mV
AP 1-2 Amplitude Change Percent -9.5124 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.4348 %
AP 1-2 AHP Depth Percent Change -0.3508 %
Input Resistance 178.5448 MΩ
AP 1 Delay Mean 5.2100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 35.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 36.9300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1837 %/ms
Accommodation at Steady State Mean -86.5685 %
Accommodation Rate Mean at Steady State 103.0248 ms
ISI CV 3.5185
ISI Median 144.5800 ms
ISI Burst Mean Change 42.0052 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.9800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.4000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.6850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2145.4800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11804.8 µm2
Number of Stems 3.0
Number of Bifurcations 42.0
Number of Branches 86.0
Overall Width 472.616 µm
Overall Height 512.935 µm
Overall Depth 127.2 µm
Average Diameter 0.671675 µm
Total Length 4492.03 µm
Total Surface 10156.3 µm2
Total Volume 5395.16 µm3
Max Euclidean Distance 500.679 µm
Max Path Distance 575.198 µm
Max Branch Order 10.0
Average Contraction 0.954923
Total Fragmentation 4251.0
Partition Asymmetry 0.52479
Average Rall's Ratio 1.28478
Average Bifurcation Angle Local 49.1852 °
Average Bifurcation Angle Remote 60.8364 °
Fractal Dimension 1.00961
Complexity Summary
State Equations 2527
Optimal Time-Step 0.00789 ms
Relative Complexity 627.99 HH
Model Size
Sections 86
Compartments 228
State Equations 2527
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00789 ms
Optimal Time-Step Error 0.26 %
Optimal Time-Step Benchmark Run Time 627.99 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.66 %
Max. Stable Time-Step Benchmark Run Time 1238.25 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16560 Hz
CVODE Steps Per AP 345
CVODE Benchmark Run Time 651.98 HH
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