Layer 6 Burst Irregular Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000261
bIR215_L6_LBC_f0665c9d1a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000261
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.10 mV
Rheobase Current Interval (0.15564, 0.15747] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -70.00 mV) 0.0296 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 7.0946 mV
AP 1 Steady State Amplitude Change 9.4565 mV
AP 1 Amplitude 74.0482 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 4.5800 ms
AP 1 Rate of Change Peak to Trough -19.6546 mV/ms
AP 1 AHP Depth 15.9700 mV
AP2 Amplitude 66.9536 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 5.1300 ms
AP 2 Rate of Change Peak to Trough -16.2739 mV/ms
AP 2 AHP Depth 16.5318 mV
AP 1-2 Amplitude Change Percent -9.5811 %
AP 1-2 Half Width Change Percent 7.1429 %
AP 1-2 Rate of Change Peak to Trough Percent Change -17.2004 %
AP 1-2 AHP Depth Percent Change 3.5179 %
Input Resistance 199.7242 MΩ
AP 1 Delay Mean 7.8100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 36.3900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 31.8400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1290 %/ms
Accommodation at Steady State Mean -88.5340 %
Accommodation Rate Mean at Steady State 125.3843 ms
ISI CV 3.1217
ISI Median 142.3800 ms
ISI Burst Mean Change 22.8132 %
Spike Rate (Strong Stimulation) 14.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.9600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.5050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2082.9700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 80.6468 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5638.92 µm2
Number of Stems 7.0
Number of Bifurcations 19.0
Number of Branches 44.0
Overall Width 378.579 µm
Overall Height 518.91 µm
Overall Depth 224.4 µm
Average Diameter 0.952032 µm
Total Length 3853.0 µm
Total Surface 9891.23 µm2
Total Volume 3541.3 µm3
Max Euclidean Distance 424.543 µm
Max Path Distance 467.691 µm
Max Branch Order 5.0
Average Contraction 0.968902
Total Fragmentation 965.0
Partition Asymmetry 0.549123
Average Rall's Ratio 2.33375
Average Bifurcation Angle Local 14.383 °
Average Bifurcation Angle Remote 35.3105 °
Fractal Dimension 1.00664
Complexity Summary
State Equations 2197
Optimal Time-Step 0.00784 ms
Relative Complexity 540.95 HH
Model Size
Sections 44
Compartments 198
State Equations 2197
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00784 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 540.95 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.23 %
Max. Stable Time-Step Benchmark Run Time 1060.11 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16909 Hz
CVODE Steps Per AP 365
CVODE Benchmark Run Time 573.42 HH
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