Layer 6 Burst Irregular Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, burst irregular large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000259
bIR215_L6_LBC_d854e4228e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000259
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -78.16 mV
Rheobase Current Interval (0.12360, 0.12451] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -70.00 mV) 0.0305 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 9.5927 mV
AP 1 Steady State Amplitude Change 9.8425 mV
AP 1 Amplitude 89.8198 mV
AP 1 Width at Half Height 0.3900 ms
AP 1 Width (Peak To Trough) 1.9300 ms
AP 1 Rate of Change Peak to Trough -60.9256 mV/ms
AP 1 AHP Depth 27.7666 mV
AP2 Amplitude 80.2271 mV
AP2 Width at Half Height 0.3900 ms
AP 2 Width (Peak to Trough) 1.8800 ms
AP 2 Rate of Change Peak to Trough -57.8435 mV/ms
AP 2 AHP Depth 28.5187 mV
AP 1-2 Amplitude Change Percent -10.6799 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.0588 %
AP 1-2 AHP Depth Percent Change 2.7087 %
Input Resistance 384.4315 MΩ
AP 1 Delay Mean 4.3800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 514.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 394.9500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 100.0000 %
Accommodation Rate to Steady State 0.1943 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 4.1359
ISI Median 301.3650 ms
ISI Burst Mean Change -45.2239 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.7900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 22.6000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.8100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2414.2700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 13641.8 µm2
Number of Stems 6.0
Number of Bifurcations 8.0
Number of Branches 21.0
Overall Width 137.347 µm
Overall Height 611.166 µm
Overall Depth 62.18 µm
Average Diameter 0.944166 µm
Total Length 1504.16 µm
Total Surface 3673.65 µm2
Total Volume 3997.35 µm3
Max Euclidean Distance 445.507 µm
Max Path Distance 465.123 µm
Max Branch Order 3.0
Average Contraction 0.976832
Total Fragmentation 674.0
Partition Asymmetry 0.375
Average Rall's Ratio 0.963333
Average Bifurcation Angle Local 91.0941 °
Average Bifurcation Angle Remote 73.0529 °
Fractal Dimension 1.00381
Complexity Summary
Relative Complexity 179.58 HH
State Equations 822
Optimal Time-Step 0.00767 ms
Model Size
Sections 23
Compartments 73
State Equations 822
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16244 Hz
CVODE Steps Per AP 37
CVODE Benchmark Run Time 179.58 HH
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