Layer 6 Burst Irregular Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst irregular double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000253
bIR215_L6_DBC_53b6888784_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000253
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.50 mV
Rheobase Current Interval (0.11673, 0.11787] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0246 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 5.9045 mV
AP 1 Steady State Amplitude Change 7.0022 mV
AP 1 Amplitude 84.9653 mV
AP 1 Width at Half Height 0.4300 ms
AP 1 Width (Peak To Trough) 2.4600 ms
AP 1 Rate of Change Peak to Trough -43.1825 mV/ms
AP 1 AHP Depth 21.2637 mV
AP2 Amplitude 79.0608 mV
AP2 Width at Half Height 0.4400 ms
AP 2 Width (Peak to Trough) 2.4900 ms
AP 2 Rate of Change Peak to Trough -40.3427 mV/ms
AP 2 AHP Depth 21.3924 mV
AP 1-2 Amplitude Change Percent -6.9493 %
AP 1-2 Half Width Change Percent 2.3256 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.5764 %
AP 1-2 AHP Depth Percent Change 0.6056 %
Input Resistance 279.6004 MΩ
AP 1 Delay Mean 5.7300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 35.6800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.9250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1225 %/ms
Accommodation at Steady State Mean -86.4712 %
Accommodation Rate Mean at Steady State 119.6134 ms
ISI CV 3.3341
ISI Median 140.8200 ms
ISI Burst Mean Change 26.5442 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.1000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.2050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2125.0100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 78.0773 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5724.89 µm2
Number of Stems 3.0
Number of Bifurcations 47.0
Number of Branches 96.0
Overall Width 401.359 µm
Overall Height 747.084 µm
Overall Depth 126.64 µm
Average Diameter 0.575847 µm
Total Length 3835.17 µm
Total Surface 7119.58 µm2
Total Volume 2642.61 µm3
Max Euclidean Distance 557.244 µm
Max Path Distance 599.086 µm
Max Branch Order 11.0
Average Contraction 0.965092
Total Fragmentation 2711.0
Partition Asymmetry 0.603218
Average Rall's Ratio 2.29437
Average Bifurcation Angle Local 57.1998 °
Average Bifurcation Angle Remote 71.3437 °
Fractal Dimension 1.00719
Complexity Summary
Relative Complexity 670.70 HH
State Equations 2384
Optimal Time-Step 0.00762 ms
Model Size
Sections 97
Compartments 215
State Equations 2384
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17378 Hz
CVODE Steps Per AP 412
CVODE Benchmark Run Time 670.70 HH
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