Layer 6 Burst Irregular Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000252
bIR215_L6_DBC_0271760b42_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000252
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.17 mV
Rheobase Current Interval (0.16663, 0.16823] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0338 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 7.2625 mV
AP 1 Steady State Amplitude Change 9.1787 mV
AP 1 Amplitude 79.2421 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 2.9500 ms
AP 1 Rate of Change Peak to Trough -33.3622 mV/ms
AP 1 AHP Depth 19.1765 mV
AP2 Amplitude 71.9796 mV
AP2 Width at Half Height 0.4900 ms
AP 2 Width (Peak to Trough) 3.1800 ms
AP 2 Rate of Change Peak to Trough -28.4683 mV/ms
AP 2 AHP Depth 18.5495 mV
AP 1-2 Amplitude Change Percent -9.1650 %
AP 1-2 Half Width Change Percent 6.5217 %
AP 1-2 Rate of Change Peak to Trough Percent Change -14.6692 %
AP 1-2 AHP Depth Percent Change -3.2693 %
Input Resistance 190.9533 MΩ
AP 1 Delay Mean 6.4400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 34.5800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.6850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1969 %/ms
Accommodation at Steady State Mean -88.5107 %
Accommodation Rate Mean at Steady State 124.3770 ms
ISI CV 3.1982
ISI Median 129.0900 ms
ISI Burst Mean Change 18.0881 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.5900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.3800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2101.3400 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.9326 Hz
Frequency Filter Pass Below 45.0674 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8381.24 µm2
Number of Stems 5.0
Number of Bifurcations 37.0
Number of Branches 78.0
Overall Width 170.545 µm
Overall Height 970.074 µm
Overall Depth 177.57 µm
Average Diameter 0.900764 µm
Total Length 4233.05 µm
Total Surface 11290.0 µm2
Total Volume 5843.15 µm3
Max Euclidean Distance 794.795 µm
Max Path Distance 830.014 µm
Max Branch Order 16.0
Average Contraction 0.961823
Total Fragmentation 4757.0
Partition Asymmetry 0.636207
Average Rall's Ratio 0.690357
Average Bifurcation Angle Local 47.0446 °
Average Bifurcation Angle Remote 56.2112 °
Fractal Dimension 1.00843
Complexity Summary
State Equations 2494
Optimal Time-Step 0.00791 ms
Relative Complexity 630.60 HH
Model Size
Sections 79
Compartments 225
State Equations 2494
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00791 ms
Optimal Time-Step Error 0.26 %
Optimal Time-Step Benchmark Run Time 630.60 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.23 %
Max. Stable Time-Step Benchmark Run Time 1246.24 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17997 Hz
CVODE Steps Per AP 465
CVODE Benchmark Run Time 742.65 HH
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