Layer 5 Burst Irregular Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: burst irregular,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000246
bIR215_L5_NBC_cb87ec754a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000246
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.71 mV
Rheobase Current Interval (0.13184, 0.13321] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0261 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 6.6748 mV
AP 1 Steady State Amplitude Change 7.3813 mV
AP 1 Amplitude 80.2353 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 2.8400 ms
AP 1 Rate of Change Peak to Trough -36.0541 mV/ms
AP 1 AHP Depth 22.1585 mV
AP2 Amplitude 73.5605 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.9900 ms
AP 2 Rate of Change Peak to Trough -31.9111 mV/ms
AP 2 AHP Depth 21.8536 mV
AP 1-2 Amplitude Change Percent -8.3190 %
AP 1-2 Half Width Change Percent 4.0816 %
AP 1-2 Rate of Change Peak to Trough Percent Change -11.4912 %
AP 1-2 AHP Depth Percent Change -1.3757 %
Input Resistance 270.7750 MΩ
AP 1 Delay Mean 6.1100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 36.8000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 40.6150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1939 %/ms
Accommodation at Steady State Mean -88.3165 %
Accommodation Rate Mean at Steady State 104.1313 ms
ISI CV 3.2426
ISI Median 159.8000 ms
ISI Burst Mean Change 64.6790 %
Spike Rate (Strong Stimulation) 13.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.5000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.1700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.1150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2133.3200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 77.6401 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6626.6 µm2
Number of Stems 6.0
Number of Bifurcations 27.0
Number of Branches 59.0
Overall Width 281.714 µm
Overall Height 712.495 µm
Overall Depth 185.05 µm
Average Diameter 0.567742 µm
Total Length 3768.2 µm
Total Surface 7058.43 µm2
Total Volume 3114.54 µm3
Max Euclidean Distance 572.569 µm
Max Path Distance 651.524 µm
Max Branch Order 7.0
Average Contraction 0.936719
Total Fragmentation 3386.0
Partition Asymmetry 0.701085
Average Rall's Ratio 0.708478
Average Bifurcation Angle Local 19.6632 °
Average Bifurcation Angle Remote 67.5667 °
Fractal Dimension 1.01336
Complexity Summary
State Equations 2153
Optimal Time-Step 0.00768 ms
Relative Complexity 564.43 HH
Model Size
Sections 60
Compartments 194
State Equations 2153
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 564.43 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.39 %
Max. Stable Time-Step Benchmark Run Time 1083.48 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17419 Hz
CVODE Steps Per AP 439
CVODE Benchmark Run Time 621.80 HH
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