Layer 5 Burst Irregular Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: burst irregular,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000244
bIR215_L5_NBC_83f56a1270_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000244
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.53 mV
Rheobase Current Interval (0.15656, 0.15793] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0336 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 11.4646 mV
AP 1 Steady State Amplitude Change 12.8550 mV
AP 1 Amplitude 87.2687 mV
AP 1 Width at Half Height 0.4000 ms
AP 1 Width (Peak To Trough) 1.9200 ms
AP 1 Rate of Change Peak to Trough -59.0491 mV/ms
AP 1 AHP Depth 26.1056 mV
AP2 Amplitude 75.8041 mV
AP2 Width at Half Height 0.3900 ms
AP 2 Width (Peak to Trough) 1.9200 ms
AP 2 Rate of Change Peak to Trough -54.5013 mV/ms
AP 2 AHP Depth 28.8384 mV
AP 1-2 Amplitude Change Percent -13.1371 %
AP 1-2 Half Width Change Percent -2.5000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.7018 %
AP 1-2 AHP Depth Percent Change 10.4681 %
Input Resistance 258.9867 MΩ
AP 1 Delay Mean 4.5900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 40.0800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 68.2300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0804 %/ms
Accommodation at Steady State Mean -80.0621 %
Accommodation Rate Mean at Steady State 109.1114 ms
ISI CV 4.0452
ISI Median 161.5100 ms
ISI Burst Mean Change 184.5027 %
Spike Rate (Strong Stimulation) 14.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.7800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.0900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.4200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2205.5300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 75.2638 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 12504.6 µm2
Number of Stems 8.0
Number of Bifurcations 29.0
Number of Branches 65.0
Overall Width 379.063 µm
Overall Height 536.954 µm
Overall Depth 188.09 µm
Average Diameter 0.69516 µm
Total Length 4551.55 µm
Total Surface 7676.39 µm2
Total Volume 4788.81 µm3
Max Euclidean Distance 480.125 µm
Max Path Distance 551.311 µm
Max Branch Order 7.0
Average Contraction 0.937367
Total Fragmentation 1603.0
Partition Asymmetry 0.562069
Average Rall's Ratio 0.698235
Average Bifurcation Angle Local 61.0403 °
Average Bifurcation Angle Remote 65.9748 °
Fractal Dimension 1.00962
Complexity Summary
State Equations 2483
Optimal Time-Step 0.00542 ms
Relative Complexity 991.37 HH
Model Size
Sections 66
Compartments 224
State Equations 2483
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00542 ms
Optimal Time-Step Error 0.13 %
Optimal Time-Step Benchmark Run Time 991.37 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.49 %
Max. Stable Time-Step Benchmark Run Time 2687.62 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17928 Hz
CVODE Steps Per AP 618
CVODE Benchmark Run Time 852.39 HH
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