Layer 5 Burst Irregular Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 5
Keywords: burst irregular,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000237
bIR215_L5_MC_7eeb7cff0f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000237
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.68 mV
Rheobase Current Interval (0.17944, 0.18127] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0313 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 6.3731 mV
AP 1 Steady State Amplitude Change 7.2944 mV
AP 1 Amplitude 78.4984 mV
AP 1 Width at Half Height 0.5000 ms
AP 1 Width (Peak To Trough) 2.7400 ms
AP 1 Rate of Change Peak to Trough -35.5973 mV/ms
AP 1 AHP Depth 19.0381 mV
AP2 Amplitude 72.1253 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.9700 ms
AP 2 Rate of Change Peak to Trough -30.9198 mV/ms
AP 2 AHP Depth 19.7064 mV
AP 1-2 Amplitude Change Percent -8.1187 %
AP 1-2 Half Width Change Percent 2.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.1400 %
AP 1-2 AHP Depth Percent Change 3.5103 %
Input Resistance 167.9767 MΩ
AP 1 Delay Mean 6.9000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 34.8600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.3650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.2075 %/ms
Accommodation at Steady State Mean -88.7450 %
Accommodation Rate Mean at Steady State 124.7217 ms
ISI CV 3.1532
ISI Median 126.3300 ms
ISI Burst Mean Change 17.2031 %
Spike Rate (Strong Stimulation) 16.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.2900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.9500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.8700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2072.4100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 70.2282 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6011.66 µm2
Number of Stems 3.0
Number of Bifurcations 71.0
Number of Branches 144.0
Overall Width 336.069 µm
Overall Height 654.595 µm
Overall Depth 143.37 µm
Average Diameter 0.683044 µm
Total Length 6330.36 µm
Total Surface 11948.3 µm2
Total Volume 3797.9 µm3
Max Euclidean Distance 536.325 µm
Max Path Distance 655.168 µm
Max Branch Order 13.0
Average Contraction 0.97399
Total Fragmentation 2300.0
Partition Asymmetry 0.576985
Average Rall's Ratio 0.920116
Average Bifurcation Angle Local 54.6727 °
Average Bifurcation Angle Remote 56.6942 °
Fractal Dimension 1.00427
Complexity Summary
State Equations 3638
Optimal Time-Step 0.00787 ms
Relative Complexity 953.51 HH
Model Size
Sections 141
Compartments 329
State Equations 3638
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00787 ms
Optimal Time-Step Error 0.13 %
Optimal Time-Step Benchmark Run Time 953.51 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.29 %
Max. Stable Time-Step Benchmark Run Time 1875.93 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17450 Hz
CVODE Steps Per AP 345
CVODE Benchmark Run Time 1031.68 HH
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