Layer 5 Burst Irregular Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: burst irregular,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000232
bIR215_L5_DBC_08b1fddce5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000232
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.09 mV
Rheobase Current Interval (0.17029, 0.17212] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0393 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 7.1085 mV
AP 1 Steady State Amplitude Change 11.7159 mV
AP 1 Amplitude 74.5494 mV
AP 1 Width at Half Height 0.5200 ms
AP 1 Width (Peak To Trough) 2.8100 ms
AP 1 Rate of Change Peak to Trough -31.5909 mV/ms
AP 1 AHP Depth 14.2210 mV
AP2 Amplitude 67.4410 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 3.2800 ms
AP 2 Rate of Change Peak to Trough -24.8506 mV/ms
AP 2 AHP Depth 14.0691 mV
AP 1-2 Amplitude Change Percent -9.5352 %
AP 1-2 Half Width Change Percent 7.6923 %
AP 1-2 Rate of Change Peak to Trough Percent Change -21.3360 %
AP 1-2 AHP Depth Percent Change -1.0675 %
Input Resistance 150.0846 MΩ
AP 1 Delay Mean 7.5000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 33.8500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 28.0350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -57.1429 %
Steady State Accommodation Mean -57.1429 %
Accommodation Rate to Steady State -0.2148 %/ms
Accommodation at Steady State Mean -89.1286 %
Accommodation Rate Mean at Steady State 147.7930 ms
ISI CV 2.9913
ISI Median 114.6200 ms
ISI Burst Mean Change 12.7894 %
Spike Rate (Strong Stimulation) 17.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 15.9800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.8950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2060.8100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 69.9652 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4654.39 µm2
Number of Stems 4.0
Number of Bifurcations 52.0
Number of Branches 107.0
Overall Width 370.984 µm
Overall Height 660.008 µm
Overall Depth 260.41 µm
Average Diameter 0.732229 µm
Total Length 6921.23 µm
Total Surface 14702.7 µm2
Total Volume 4321.89 µm3
Max Euclidean Distance 475.851 µm
Max Path Distance 855.287 µm
Max Branch Order 11.0
Average Contraction 0.949842
Total Fragmentation 5939.0
Partition Asymmetry 0.490463
Average Rall's Ratio 0.97881
Average Bifurcation Angle Local 30.0188 °
Average Bifurcation Angle Remote 54.3598 °
Fractal Dimension 1.00953
Complexity Summary
State Equations 3957
Optimal Time-Step 0.00775 ms
Relative Complexity 1090.67 HH
Model Size
Sections 108
Compartments 358
State Equations 3957
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.36 %
Optimal Time-Step Benchmark Run Time 1090.67 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.75 %
Max. Stable Time-Step Benchmark Run Time 2111.32 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18251 Hz
CVODE Steps Per AP 354
CVODE Benchmark Run Time 1210.68 HH
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