Layer 5 Burst Irregular Bipolar Cell (5)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 5
Keywords: burst irregular,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000231
bIR215_L5_BP_f920d1af2c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000231
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.67 mV
Rheobase Current Interval (0.08057, 0.08148] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0160 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 4.0204 mV
AP 1 Steady State Amplitude Change 4.8311 mV
AP 1 Amplitude 80.7504 mV
AP 1 Width at Half Height 0.4700 ms
AP 1 Width (Peak To Trough) 2.3000 ms
AP 1 Rate of Change Peak to Trough -42.8496 mV/ms
AP 1 AHP Depth 17.8038 mV
AP2 Amplitude 76.7299 mV
AP2 Width at Half Height 0.4800 ms
AP 2 Width (Peak to Trough) 2.4000 ms
AP 2 Rate of Change Peak to Trough -39.5726 mV/ms
AP 2 AHP Depth 18.2444 mV
AP 1-2 Amplitude Change Percent -4.9788 %
AP 1-2 Half Width Change Percent 2.1277 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.6476 %
AP 1-2 AHP Depth Percent Change 2.4749 %
Input Resistance 331.5922 MΩ
AP 1 Delay Mean 8.4100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 36.8300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.2900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1561 %/ms
Accommodation at Steady State Mean -87.7642 %
Accommodation Rate Mean at Steady State 143.4304 ms
ISI CV 3.1022
ISI Median 120.8150 ms
ISI Burst Mean Change 13.1597 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.4600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.4500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.2100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2055.7900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 119.1987 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 297.785 µm
Overall Height 541.742 µm
Overall Depth 298.4 µm
Average Diameter 0.633859 µm
Total Length 3813.69 µm
Total Surface 6640.36 µm2
Total Volume 1369.67 µm3
Max Euclidean Distance 385.127 µm
Max Path Distance 455.329 µm
Max Branch Order 6.0
Average Contraction 0.972064
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 34.1365 °
Average Bifurcation Angle Remote 49.9268 °
Fractal Dimension 1.00551
Complexity Summary
State Equations 2120
Optimal Time-Step 0.00792 ms
Relative Complexity 530.21 HH
Model Size
Sections 65
Compartments 191
State Equations 2120
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00792 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 530.21 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.14 %
Max. Stable Time-Step Benchmark Run Time 1049.44 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16449 Hz
CVODE Steps Per AP 476
CVODE Benchmark Run Time 585.62 HH
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