Layer 5 Burst Irregular Bipolar Cell (3)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 5
Keywords: burst irregular,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar, biophysical, burst irregular bipolar cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000229
bIR215_L5_BP_6687408de7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000229
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.85 mV
Rheobase Current Interval (0.08240, 0.08331] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0145 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 3.8499 mV
AP 1 Steady State Amplitude Change 4.9810 mV
AP 1 Amplitude 80.3675 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 2.4000 ms
AP 1 Rate of Change Peak to Trough -40.6280 mV/ms
AP 1 AHP Depth 17.1398 mV
AP2 Amplitude 76.5176 mV
AP2 Width at Half Height 0.4900 ms
AP 2 Width (Peak to Trough) 2.5900 ms
AP 2 Rate of Change Peak to Trough -36.2170 mV/ms
AP 2 AHP Depth 17.2845 mV
AP 1-2 Amplitude Change Percent -4.7903 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.8571 %
AP 1-2 AHP Depth Percent Change 0.8441 %
Input Resistance 348.7336 MΩ
AP 1 Delay Mean 8.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 35.8100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.6400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1519 %/ms
Accommodation at Steady State Mean -88.2072 %
Accommodation Rate Mean at Steady State 136.5132 ms
ISI CV 3.1323
ISI Median 120.8400 ms
ISI Burst Mean Change 13.5447 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.5000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.2100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.9500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2061.7000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.1481 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 330.181 µm
Overall Height 394.391 µm
Overall Depth 263.95 µm
Average Diameter 0.633331 µm
Total Length 3514.96 µm
Total Surface 6122.06 µm2
Total Volume 1295.6 µm3
Max Euclidean Distance 344.865 µm
Max Path Distance 355.943 µm
Max Branch Order 6.0
Average Contraction 0.971046
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 34.1412 °
Average Bifurcation Angle Remote 49.3195 °
Fractal Dimension 1.0057
Complexity Summary
Relative Complexity 523.83 HH
State Equations 1988
Optimal Time-Step 0.00792 ms
Model Size
Sections 65
Compartments 179
State Equations 1988
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16309 Hz
CVODE Steps Per AP 394
CVODE Benchmark Run Time 523.83 HH
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