Layer 5 Burst Irregular Bipolar Cell (1)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 5
Keywords: burst irregular,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000227
bIR215_L5_BP_03b3d4a19f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000227
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.75 mV
Rheobase Current Interval (0.08514, 0.08606] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0154 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 4.0106 mV
AP 1 Steady State Amplitude Change 5.1216 mV
AP 1 Amplitude 80.3315 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 2.5200 ms
AP 1 Rate of Change Peak to Trough -38.5710 mV/ms
AP 1 AHP Depth 16.8675 mV
AP2 Amplitude 76.3210 mV
AP2 Width at Half Height 0.5000 ms
AP 2 Width (Peak to Trough) 2.7000 ms
AP 2 Rate of Change Peak to Trough -34.5531 mV/ms
AP 2 AHP Depth 16.9724 mV
AP 1-2 Amplitude Change Percent -4.9925 %
AP 1-2 Half Width Change Percent 2.0408 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.4170 %
AP 1-2 AHP Depth Percent Change 0.6221 %
Input Resistance 334.0229 MΩ
AP 1 Delay Mean 7.9500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 35.4100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.3050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1581 %/ms
Accommodation at Steady State Mean -88.3106 %
Accommodation Rate Mean at Steady State 138.9621 ms
ISI CV 3.0852
ISI Median 119.2600 ms
ISI Burst Mean Change 13.4377 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.4500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.9000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.7100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2056.2500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 77.1465 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 315.464 µm
Overall Height 460.596 µm
Overall Depth 254.11 µm
Average Diameter 0.633331 µm
Total Length 3703.35 µm
Total Surface 6469.06 µm2
Total Volume 1346.27 µm3
Max Euclidean Distance 338.372 µm
Max Path Distance 382.729 µm
Max Branch Order 6.0
Average Contraction 0.972042
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 34.4657 °
Average Bifurcation Angle Remote 50.4453 °
Fractal Dimension 1.00543
Complexity Summary
State Equations 2142
Optimal Time-Step 0.00779 ms
Relative Complexity 543.73 HH
Model Size
Sections 65
Compartments 193
State Equations 2142
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.13 %
Optimal Time-Step Benchmark Run Time 543.73 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.46 %
Max. Stable Time-Step Benchmark Run Time 1058.49 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16245 Hz
CVODE Steps Per AP 408
CVODE Benchmark Run Time 565.97 HH
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