Layer 4 Burst Irregular Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: burst irregular,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000225
bIR215_L4_DBC_e57b56d14c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000225
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.29 mV
Rheobase Current Interval (0.13733, 0.13847] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0273 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 5.2661 mV
AP 1 Steady State Amplitude Change 6.0640 mV
AP 1 Amplitude 85.0758 mV
AP 1 Width at Half Height 0.4200 ms
AP 1 Width (Peak To Trough) 1.9500 ms
AP 1 Rate of Change Peak to Trough -54.6449 mV/ms
AP 1 AHP Depth 21.4817 mV
AP2 Amplitude 79.8097 mV
AP2 Width at Half Height 0.4300 ms
AP 2 Width (Peak to Trough) 1.9700 ms
AP 2 Rate of Change Peak to Trough -51.0799 mV/ms
AP 2 AHP Depth 20.8178 mV
AP 1-2 Amplitude Change Percent -6.1899 %
AP 1-2 Half Width Change Percent 2.3810 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.5238 %
AP 1-2 AHP Depth Percent Change -3.0906 %
Input Resistance 209.4216 MΩ
AP 1 Delay Mean 4.9700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 32.4300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.5550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1452 %/ms
Accommodation at Steady State Mean -88.1694 %
Accommodation Rate Mean at Steady State 127.9030 ms
ISI CV 3.2196
ISI Median 121.1000 ms
ISI Burst Mean Change 15.2586 %
Spike Rate (Strong Stimulation) 17.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.5700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.1800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.7250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2100.4000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.1947 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5696.29 µm2
Number of Stems 3.0
Number of Bifurcations 31.0
Number of Branches 64.0
Overall Width 194.335 µm
Overall Height 862.213 µm
Overall Depth 131.36 µm
Average Diameter 0.943876 µm
Total Length 3157.54 µm
Total Surface 9186.47 µm2
Total Volume 3879.08 µm3
Max Euclidean Distance 636.79 µm
Max Path Distance 666.625 µm
Max Branch Order 7.0
Average Contraction 0.955882
Total Fragmentation 1289.0
Partition Asymmetry 0.617122
Average Rall's Ratio 1.174
Average Bifurcation Angle Local 50.8782 °
Average Bifurcation Angle Remote 68.0364 °
Fractal Dimension 1.00574
Complexity Summary
State Equations 1900
Optimal Time-Step 0.00779 ms
Relative Complexity 485.62 HH
Model Size
Sections 65
Compartments 171
State Equations 1900
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 485.62 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.64 %
Max. Stable Time-Step Benchmark Run Time 944.89 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16965 Hz
CVODE Steps Per AP 410
CVODE Benchmark Run Time 523.65 HH
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