Layer 4 Burst Irregular Bitufted Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst irregular,Layer 4,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000221
bIR215_L4_BTC_d656c19ac5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000221
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.81 mV
Rheobase Current Interval (0.10849, 0.10986] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0250 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 7.6513 mV
AP 1 Steady State Amplitude Change 15.8380 mV
AP 1 Amplitude 77.9029 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 3.1300 ms
AP 1 Rate of Change Peak to Trough -30.7162 mV/ms
AP 1 AHP Depth 18.2389 mV
AP2 Amplitude 70.2516 mV
AP2 Width at Half Height 0.5400 ms
AP 2 Width (Peak to Trough) 3.5300 ms
AP 2 Rate of Change Peak to Trough -24.8954 mV/ms
AP 2 AHP Depth 17.6291 mV
AP 1-2 Amplitude Change Percent -9.8215 %
AP 1-2 Half Width Change Percent 5.8824 %
AP 1-2 Rate of Change Peak to Trough Percent Change -18.9504 %
AP 1-2 AHP Depth Percent Change -3.3434 %
Input Resistance 291.3642 MΩ
AP 1 Delay Mean 7.7900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 37.9600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.9750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.1764 %/ms
Accommodation at Steady State Mean -88.1320 %
Accommodation Rate Mean at Steady State 130.5038 ms
ISI CV 3.0852
ISI Median 152.0100 ms
ISI Burst Mean Change 25.2237 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.9400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.4800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.7600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2103.0300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.0323 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4955.95 µm2
Number of Stems 6.0
Number of Bifurcations 19.0
Number of Branches 43.0
Overall Width 247.704 µm
Overall Height 294.74 µm
Overall Depth 212.98 µm
Average Diameter 0.841585 µm
Total Length 2995.65 µm
Total Surface 6052.38 µm2
Total Volume 2457.56 µm3
Max Euclidean Distance 249.462 µm
Max Path Distance 295.095 µm
Max Branch Order 6.0
Average Contraction 0.97254
Total Fragmentation 931.0
Partition Asymmetry 0.419458
Average Rall's Ratio 0.725714
Average Bifurcation Angle Local 46.6201 °
Average Bifurcation Angle Remote 52.6706 °
Fractal Dimension 1.00587
Complexity Summary
State Equations 1647
Optimal Time-Step 0.00793 ms
Relative Complexity 417.58 HH
Model Size
Sections 44
Compartments 148
State Equations 1647
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00793 ms
Optimal Time-Step Error 0.23 %
Optimal Time-Step Benchmark Run Time 417.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.17 %
Max. Stable Time-Step Benchmark Run Time 827.76 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15893 Hz
CVODE Steps Per AP 512
CVODE Benchmark Run Time 457.70 HH
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