Layer 4 Burst Irregular Bitufted Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst irregular,Layer 4,Rat, somatosensory cortex, bitufted, biophysical, burst irregular bitufted cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000219
bIR215_L4_BTC_7ea9933f77_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000219
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.76 mV
Rheobase Current Interval (0.07965, 0.08034] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -70.00 mV) 0.0167 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 18.6802 mV
AP 1 Steady State Amplitude Change 25.8706 mV
AP 1 Amplitude 84.4122 mV
AP 1 Width at Half Height 0.4300 ms
AP 1 Width (Peak To Trough) 1.9700 ms
AP 1 Rate of Change Peak to Trough -53.6538 mV/ms
AP 1 AHP Depth 21.2859 mV
AP2 Amplitude 65.7320 mV
AP2 Width at Half Height 0.5200 ms
AP 2 Width (Peak to Trough) 2.4000 ms
AP 2 Rate of Change Peak to Trough -35.5257 mV/ms
AP 2 AHP Depth 19.5296 mV
AP 1-2 Amplitude Change Percent -22.1297 %
AP 1-2 Half Width Change Percent 20.9302 %
AP 1-2 Rate of Change Peak to Trough Percent Change -33.7872 %
AP 1-2 AHP Depth Percent Change -8.2507 %
Input Resistance 453.4494 MΩ
AP 1 Delay Mean 4.2600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 442.8100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 354.5050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 6.0919
ISI Median 322.9100 ms
ISI Burst Mean Change -38.3286 %
Spike Rate (Strong Stimulation) 14.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.8200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.3100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.0800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2396.4500 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.4718 Hz
Frequency Filter Pass Below 45.9295 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3545.28 µm2
Number of Stems 3.0
Number of Bifurcations 39.0
Number of Branches 80.0
Overall Width 198.472 µm
Overall Height 649.698 µm
Overall Depth 109.11 µm
Average Diameter 0.357926 µm
Total Length 4183.94 µm
Total Surface 4830.66 µm2
Total Volume 1680.04 µm3
Max Euclidean Distance 516.456 µm
Max Path Distance 561.97 µm
Max Branch Order 13.0
Average Contraction 0.937651
Total Fragmentation 6034.0
Partition Asymmetry 0.614774
Average Rall's Ratio 1.51333
Average Bifurcation Angle Local 51.4803 °
Average Bifurcation Angle Remote 66.4065 °
Fractal Dimension 1.01669
Complexity Summary
Relative Complexity 1464.78 HH
State Equations 2494
Optimal Time-Step 0.00764 ms
Model Size
Sections 81
Compartments 225
State Equations 2494
Variable Time-Step Complexity
CVODE Steady State Step Frequency 26199 Hz
CVODE Steps Per AP 1714
CVODE Benchmark Run Time 1464.78 HH
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